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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4d7mTDCTetracycline repressor protein class D

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4d7mTDCTetracycline repressor protein class D/1.000
2xpwOTCTetracycline repressor protein class D/0.710
4b3aTACTetracycline repressor protein class D/0.684
2tctCTCTetracycline repressor protein class D/0.679
2xrlDXTTetracycline repressor protein class D/0.675
2xb5I7TTetracycline repressor protein class D/0.665
2o7oDXTTetracycline repressor protein class D/0.658
2xpvMIYTetracycline repressor protein class D/0.639
1orkATCTetracycline repressor protein class D/0.622
5fklTDCTetracycline repressor protein class D/0.622
2trtTACTetracycline repressor protein class D/0.621
2xpuTDCTetracycline repressor protein class D/0.606
4auxXTCTetracycline repressor protein class D/0.606
2fj1CTCTetracycline repressor protein class D/0.605
5fkmTDCTetracycline repressor protein class D/0.584
2vkeTACTetracycline repressor protein class D/0.583
4abzT1CTetracycline repressor protein class D/0.569
5fkoTDCTetracycline repressor protein class D/0.563
2vkvTDCTetracycline repressor protein class D/0.557
2vprTDCTetracycline repressor protein class H/0.547
2x9dITCTetracycline repressor protein class D/0.542
4v2gITCTetracycline repressor protein class D/0.532
5fknTDCTetracycline repressor protein class D/0.513
4b1rITCTetracycline repressor protein class D/0.512
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.488
2x6o2TCTetracycline repressor protein class D/0.477
1w6hTITPlasmepsin-23.4.23.390.460
2hq9FADMll6688 protein/0.458
4j7xNAPSepiapterin reductase1.1.1.1530.452
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.450
1esmCOAPantothenate kinase2.7.1.330.449
4hwkNAPSepiapterin reductase1.1.1.1530.446
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.446
3uceNDPDehydrogenase/0.445
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.444
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.442
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2yutNAPPutative short-chain oxidoreductase/0.440
4j7uNAPSepiapterin reductase1.1.1.1530.440