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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4awsFMNNADH:flavin oxidoreductase Sye1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4awsFMNNADH:flavin oxidoreductase Sye1/1.000
4awtFMNNADH:flavin oxidoreductase Sye1/0.703
2gouFMNNADH:flavin oxidoreductase Sye1/0.666
2gqaFMNNADH:flavin oxidoreductase Sye1/0.596
1h50FMNPentaerythritol tetranitrate reductase/0.531
3p8iFMNPentaerythritol tetranitrate reductase/0.525
1icsFMN12-oxophytodienoate reductase 11.3.1.420.521
4jicFMNGTN Reductase/0.518
3p62FMNPentaerythritol tetranitrate reductase/0.516
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.514
1icqFMN12-oxophytodienoate reductase 11.3.1.420.512
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.512
1h63FMNPentaerythritol tetranitrate reductase/0.506
4tmbFMNOld yellow enzyme/0.502
3p67FMNPentaerythritol tetranitrate reductase/0.501
1h51FMNPentaerythritol tetranitrate reductase/0.500
4df2FMNNADPH dehydrogenase/0.499
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.496
3f03FMNPentaerythritol tetranitrate reductase/0.492
4b5nFMNNAD(P)H:flavin oxidoreductase Sye4/0.490
2abbFMNPentaerythritol tetranitrate reductase/0.489
3p84FMNPentaerythritol tetranitrate reductase/0.489
4rnvFMNNADPH dehydrogenase 11.6.99.10.488
3p8jFMNPentaerythritol tetranitrate reductase/0.487
4e2dFMNDehydrogenase/0.483
1bwlFMNNADPH dehydrogenase 11.6.99.10.481
1k02FMNNADPH dehydrogenase 11.6.99.10.481
3hf3FMNChromate reductase/0.481
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.480
4m5pFMNNADPH dehydrogenase/0.480
4qaiFMNNADPH dehydrogenase/0.480
4qnwFMNChanoclavine-I aldehyde reductase easA/0.480
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.478
3p82FMNPentaerythritol tetranitrate reductase/0.476
4tmcFMNOld yellow enzyme/0.476
1z41FMNNADPH dehydrogenase/0.473
4h6kFMNNADPH dehydrogenase 11.6.99.10.472
4rnwFMNNADPH dehydrogenase 11.6.99.10.471
2q3oFMN12-oxophytodienoate reductase 31.3.1.420.469
3tjlFMNNADPH dehydrogenase/0.469
1vyrFMNPentaerythritol tetranitrate reductase/0.468
3gkaFMNN-ethylmaleimide reductase/0.463
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.463
1kbiFMNCytochrome b2, mitochondrial1.1.2.30.461
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.461
3atyFMNProstaglandin F2a synthase/0.461
4e2bFMNDehydrogenase/0.461
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.459
3p74FMNPentaerythritol tetranitrate reductase/0.459
1bwkFMNNADPH dehydrogenase 11.6.99.10.458
3q7fED2Uncharacterized protein/0.458
3vkjFNRIsopentenyl-diphosphate delta-isomerase/0.458
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.458
2oz57XYUncharacterized protein/0.456
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.456
2zsaADPPantothenate kinase2.7.1.330.456
1goxFMNPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.449
2dxiATPGlutamate--tRNA ligase6.1.1.170.449
2hpvFMNFMN-dependent NADH-azoreductase1.70.449
4gi5FADPutative NAD(P)H dehydrogenase (Quinone)/0.449
2iko7IGRenin3.4.23.150.448
2jb4A14Isopenicillin N synthase1.21.3.10.448
3b03VNRIsopentenyl-diphosphate delta-isomerase/0.448
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.448
4q0kGA3Phytohormone-binding protein/0.448
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3ebf332Nitric oxide synthase, inducible1.14.13.390.447
4n9qFMNFMN-dependent NADH-azoreductase 1/0.447
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1oycFMNNADPH dehydrogenase 11.6.99.10.445
2gjlFMNNitronate monooxygenase1.13.12.160.445
3l5lFMNXenobiotic reductase/0.445
2ikuLIYRenin3.4.23.150.444
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.444
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.444
1k7fIAVTryptophan synthase alpha chain/0.443
1oyaFMNNADPH dehydrogenase 11.6.99.10.443
1z44FMNNADPH dehydrogenase/0.442
2bf4FADNADPH--cytochrome P450 reductase/0.442
2iviACWIsopenicillin N synthase1.21.3.10.442
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.442
4uymVOR14-alpha sterol demethylase Cyp51B/0.442
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.441
4eb5PLPCysteine desulfurase IscS 2/0.441
1ay0TPPTransketolase 12.2.1.10.440
1hb3SCVIsopenicillin N synthase1.21.3.10.440
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440
2nliFMNLactate oxidase/0.440
4eb7PLPCysteine desulfurase IscS 2/0.440