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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4aa4QC0Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4aa4QC0Mitogen-activated protein kinase 14/1.000
4aacAAVMitogen-activated protein kinase 14/0.778
4aa5NQBMitogen-activated protein kinase 14/0.660
3fklFKLMitogen-activated protein kinase 14/0.623
2balPQAMitogen-activated protein kinase 14/0.609
4kip1R9Mitogen-activated protein kinase 14/0.588
3nww3NWMitogen-activated protein kinase 14/0.587
3iphG11Mitogen-activated protein kinase 14/0.583
4kiq1RAMitogen-activated protein kinase 14/0.583
3fln3FNMitogen-activated protein kinase 14/0.582
3fskRO6Mitogen-activated protein kinase 14/0.579
3hl7I47Mitogen-activated protein kinase 14/0.562
3mpt1GKMitogen-activated protein kinase 14/0.537
4kin1M8Mitogen-activated protein kinase 14/0.533
3dt1P40Mitogen-activated protein kinase 14/0.530
3flwFLWMitogen-activated protein kinase 14/0.527
4lopSB4Mitogen-activated protein kinase 14/0.522
3mvl38PMitogen-activated protein kinase 14/0.518
3s4qNK0Mitogen-activated protein kinase 14/0.516
3ocgOCGMitogen-activated protein kinase 14/0.509
3uvqFS8Mitogen-activated protein kinase 14/0.508
3flyFLYMitogen-activated protein kinase 14/0.503
2rg6287Mitogen-activated protein kinase 14/0.502
3fi4FI4Mitogen-activated protein kinase 14/0.502
3flzFLZMitogen-activated protein kinase 14/0.499
3fmh533Mitogen-activated protein kinase 14/0.499
3hvcGG5Mitogen-activated protein kinase 14/0.498
4looSB4Mitogen-activated protein kinase 14/0.495
3gfeP37Mitogen-activated protein kinase 14/0.493
3u8w09JMitogen-activated protein kinase 14/0.485
1zyjBI5Mitogen-activated protein kinase 14/0.484
2rg5279Mitogen-activated protein kinase 14/0.483
3fmkFMKMitogen-activated protein kinase 14/0.479
4loqSB4Mitogen-activated protein kinase 14/0.479
3roc29AMitogen-activated protein kinase 14/0.477
3mvm39PMitogen-activated protein kinase 14/0.474
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.473
3l8xN4DMitogen-activated protein kinase 14/0.472
3uyt0CKCasein kinase I isoform delta2.7.11.10.471
3mpaSB2Mitogen-activated protein kinase 14/0.467
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
4ic7ANPMitogen-activated protein kinase 72.7.11.240.466
4nk92K5Fibroblast growth factor receptor 1/0.465
3hllI45Mitogen-activated protein kinase 14/0.462
3uibSB2Putative mitogen-activated protein kinase/0.461
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.461
2ghlLIBMitogen-activated protein kinase 14/0.460
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.460
3w33W19Epidermal growth factor receptor2.7.10.10.459
1ywrLI9Mitogen-activated protein kinase 14/0.458
4eh60ONMitogen-activated protein kinase 14/0.458
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.457
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.457
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
3gc9B45Mitogen-activated protein kinase 112.7.11.240.453
3ol5SAWCamphor 5-monooxygenase1.14.15.10.452
1zz2B11Mitogen-activated protein kinase 14/0.451
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.450
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.450
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.450
1xddAAYIntegrin alpha-L/0.449
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.449
3itzP66Mitogen-activated protein kinase 14/0.449
1ouk084Mitogen-activated protein kinase 14/0.448
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.448
4yuqKS1Calmodulin-like domain protein kinase/0.448
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.447
2qo9ANPEphrin type-A receptor 32.7.10.10.447
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.447
4fv6E57Mitogen-activated protein kinase 12.7.11.240.446
4g7gVFVLanosterol 14-alpha-demethylase/0.446
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.446
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.445
3nbwTR4Ketohexokinase/0.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.444
3vryB43Tyrosine-protein kinase HCK2.7.10.20.443
4g3jVNTLanosterol 14-alpha-demethylase/0.443
3qaiXNNKetohexokinase/0.442
3vjoANPEpidermal growth factor receptor2.7.10.10.442
3vs3VSETyrosine-protein kinase HCK2.7.10.20.442
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4gk3L87Ephrin type-A receptor 32.7.10.10.442
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.441
1u4dDBQActivated CDC42 kinase 1/0.441
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4nks2M2Fibroblast growth factor receptor 1/0.441
4gk2L66Ephrin type-A receptor 32.7.10.10.440
4hjoAQ4Epidermal growth factor receptor2.7.10.10.440
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.440