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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3zpqXF5Beta-1 adrenergic receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3zpqXF5Beta-1 adrenergic receptor/1.000
2vt4P32Beta-1 adrenergic receptor/0.632
4bvnP32Beta-1 adrenergic receptor/0.627
2ycyP32Beta-1 adrenergic receptor/0.627
5f8uP32Beta-1 adrenergic receptor/0.625
2ycxP32Beta-1 adrenergic receptor/0.622
5d6lCAUBeta-2 adrenergic receptor/0.619
2y02WHJBeta-1 adrenergic receptor/0.616
5d5bCAUBeta-2 adrenergic receptor/0.613
2ycwCAUBeta-1 adrenergic receptor/0.610
2rh1CAUBeta-2 adrenergic receptor/0.607
2yczI32Beta-1 adrenergic receptor/0.607
2y01Y00Beta-1 adrenergic receptor/0.602
2y035FWBeta-1 adrenergic receptor/0.602
3d4sTIMBeta-2 adrenergic receptor/0.599
5d5aCAUBeta-2 adrenergic receptor/0.596
3ny8JRZBeta-2 adrenergic receptor/0.595
2y0468HBeta-1 adrenergic receptor/0.588
4amjCVDBeta-1 adrenergic receptor/0.586
4gbrCAUBeta-2 adrenergic receptor/0.586
4amiG90Beta-1 adrenergic receptor/0.580
5a8eXTKBeta-1 adrenergic receptor/0.577
5jqhCAUBeta-2 adrenergic receptor/0.567
3ny9JSZBeta-2 adrenergic receptor/0.560
4iarERM5-hydroxytryptamine receptor 1B/0.548
3nyaJTZBeta-2 adrenergic receptor/0.525
4ldeP0GBeta-2 adrenergic receptor/0.510
4iaq2GM5-hydroxytryptamine receptor 1B/0.486
4jq4IMNAldo-keto reductase family 1 member C2/0.477
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.474
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.471
3f90FMNFlavodoxin/0.466
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.465
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
5bp7SAHSAM-dependent methyltransferase/0.458
4dyn0MRNucleoprotein/0.456
1c4yIH3Prothrombin3.4.21.50.454
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.454
1jdzFMBPurine nucleoside phosphorylase/0.453
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.453
2gpjFADSiderophore-interacting protein/0.453
3cr0809Wee1-like protein kinase2.7.10.20.453
2bktRPFRenin3.4.23.150.451
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.451
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.451
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.451
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2zs9ADPPantothenate kinase2.7.1.330.449
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.448
3qe2FMNNADPH--cytochrome P450 reductase/0.448
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.448
1fmlRTLRetinol dehydratase/0.447
1oc1ASVIsopenicillin N synthase1.21.3.10.447
4bfxZVXPantothenate kinase2.7.1.330.447
4fam0SZAldo-keto reductase family 1 member C3/0.446
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2wvlGDDMannosyl-3-phosphogylcerate synthase/0.445
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3v94WYQPhosphodiesterase/0.444
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.444
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.444
1g60SAMModification methylase MboII2.1.1.720.443
3g70A5TRenin3.4.23.150.443
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.443
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.443
4e2yJHZMethyltransferase/0.443
4nc3ERM5-hydroxytryptamine receptor 2B/0.443
1disBDMDihydrofolate reductase1.5.1.30.442
1frbZSTAldose reductase-related protein 2/0.442
1ry8RUTAldo-keto reductase family 1 member C3/0.442
2in6839Wee1-like protein kinase2.7.10.20.442
2xlpNAPPutative flavin-containing monooxygenase/0.442
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.442
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.441
3sf6FDAGlutaryl-CoA dehydrogenase/0.441
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.441
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.441
4frkDWDBeta-secretase 13.4.23.460.441
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
1pd9CO4Dihydrofolate reductase1.5.1.30.440
3a1l2CCCytochrome P450/0.440
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
4lrrCF9Thymidylate synthase/0.440