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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3vs0VS0Tyrosine-protein kinase HCK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3vs0VS0Tyrosine-protein kinase HCK2.7.10.21.000
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.615
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.608
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.589
3vs1VSATyrosine-protein kinase HCK2.7.10.20.577
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.576
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.566
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.564
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.553
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.551
3vryB43Tyrosine-protein kinase HCK2.7.10.20.543
3vs3VSETyrosine-protein kinase HCK2.7.10.20.533
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.533
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.530
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.527
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.520
3w2sW2REpidermal growth factor receptor2.7.10.10.505
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.501
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.499
2c6eHPMAurora kinase A2.7.11.10.497
3w33W19Epidermal growth factor receptor2.7.10.10.495
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.488
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.476
4i22IREEpidermal growth factor receptor2.7.10.10.476
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.475
3poz03PEpidermal growth factor receptor2.7.10.10.471
4aotGW8Serine/threonine-protein kinase 102.7.11.10.470
3w18N13Aurora kinase A2.7.11.10.468
2wotZZGTGF-beta receptor type-12.7.11.300.467
1xkkFMMEpidermal growth factor receptor2.7.10.10.466
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.460
4id71G0Activated CDC42 kinase 1/0.460
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.458
2hk51BMTyrosine-protein kinase HCK2.7.10.20.455
3ttjJBIMitogen-activated protein kinase 102.7.11.240.453
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.452
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.451
3w2rW2REpidermal growth factor receptor2.7.10.10.450
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4yuqKS1Calmodulin-like domain protein kinase/0.446
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3w32W32Epidermal growth factor receptor2.7.10.10.445
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.445
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
2pwlACPFibroblast growth factor receptor 2/0.443
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.443
3ogqAB1Pol polyprotein/0.442
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.442
4gk2L66Ephrin type-A receptor 32.7.10.10.442
4nka2K7Fibroblast growth factor receptor 1/0.442
4riyADPEpidermal growth factor receptor2.7.10.10.442
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3uvqFS8Mitogen-activated protein kinase 14/0.441
2vwu7X1Ephrin type-B receptor 42.7.10.10.440