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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3uhl2NCGag-Pol polyprotein3.4.23.16

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3uhl2NCGag-Pol polyprotein3.4.23.161.000
4ye3G04Gag-Pol polyprotein3.4.23.160.553
2a1eIPFGag-Pol polyprotein3.4.23.160.548
2pk5075Protease/0.544
2ieo017Protease/0.541
3s85LK0Gag-Pol polyprotein/0.541
3a2oKNJGag-Pol polyprotein3.4.23.160.540
4hdfG52Gag-Pol polyprotein3.4.23.160.539
4j5j478Gag-Pol polyprotein3.4.23.160.538
3kdcJZPGag-Pol polyprotein3.4.23.160.537
2cem2AHPol protein/0.530
2xyfG40Gag-Pol polyprotein/0.530
3ekt017Gag-Pol polyprotein3.4.23.160.530
3zpsEQMGag-Pol polyprotein3.4.23.160.530
4hdbG52Gag-Pol polyprotein3.4.23.160.529
4rvj478Protease/0.529
3dcrKVSProtease/0.528
3ggxGGXGag-Pol polyprotein/0.528
3i2l2NCProtease/0.525
4kb9G79Protease/0.525
4njvRITProtease/0.525
1ec2BEJGag-Pol polyprotein3.4.23.160.524
3ekp478Gag-Pol polyprotein3.4.23.160.524
3sa755AProtease/0.524
1yt9OISGag-Pol polyprotein/0.522
3jw2017Gag-Pol polyprotein3.4.23.160.522
4j55031Gag-Pol polyprotein3.4.23.160.522
2xyeCXGGag-Pol polyprotein/0.521
1vijBAYGag-Pol polyprotein/0.520
3ok9G52Gag-Pol polyprotein3.4.23.160.520
2fdd385Pol protein/0.519
2fde385Gag-Pol polyprotein3.4.23.160.519
3linE13Protease/0.519
3zptM8YGag-Pol polyprotein3.4.23.160.519
1ff02NCGag-Pol polyprotein3.4.23.160.518
2fxeDR7Gag-Pol polyprotein3.4.23.160.518
2pk6O33V-1 protease/0.518
3hzc2NCProtease/0.518
4a4qUX9Pol protein/0.518
1difA85Gag-Pol polyprotein/0.517
2qd6065Gag-Pol polyprotein3.4.23.160.517
3nyg2NCGag-Pol polyprotein3.4.23.160.517
2i4vDJRV-1 protease/0.516
2i4xKGQProtease/0.516
3tl9ROCGag-Pol polyprotein3.4.23.160.516
1ec3MS3Gag-Pol polyprotein3.4.23.160.515
2nnkROCProtease/0.515
3dk1G05Gag-Pol polyprotein3.4.23.160.515
4a6bQG8Gag-Pol polyprotein3.4.23.160.515
2ien017Gag-Pol polyprotein3.4.23.160.514
2aquDR7Gag-Pol polyprotein3.4.23.160.513
3vfb031Gag-Pol polyprotein3.4.23.160.513
4djoMK5Pol polyprotein/0.513
4j54G52Gag-Pol polyprotein3.4.23.160.513
1fg62NCGag-Pol polyprotein3.4.23.160.510
1hxwRITGag-Pol polyprotein/0.510
2bpv1INGag-Pol polyprotein3.4.23.160.510
2bqvA1AProtease/0.510
2i4wKGQProtease/0.510
3ekwDR7Gag-Pol polyprotein3.4.23.160.510
3ndwRITGag-Pol polyprotein3.4.23.160.510
1hvjA78Gag-Pol polyprotein/0.509
1vikBAYGag-Pol polyprotein/0.509
2a4fAAUV-1 protease/0.509
2avm2NCGag-Pol polyprotein3.4.23.160.509
2cen4AHProtease/0.509
3ndxRITGag-Pol polyprotein3.4.23.160.509
3st5G89Gag-Pol polyprotein3.4.23.160.509
1t7i017Gag-Pol polyprotein3.4.23.160.508
3mxeK54Gag-Pol polyprotein3.4.23.160.508
3nxe2NCProtease/0.508
1fgc2NCGag-Pol polyprotein3.4.23.160.507
2qd8065Gag-Pol polyprotein3.4.23.160.507
3d1yROCGag-Pol polyprotein3.4.23.160.507
2upjU02Gag-Pol polyprotein3.4.23.160.506
3vf5031Gag-Pol polyprotein3.4.23.160.506
3zpuM8BGag-Pol polyprotein3.4.23.160.506
3nduROCGag-Pol polyprotein3.4.23.160.505
2wkz5AHGag-Pol polyprotein/0.504
3ekqROCGag-Pol polyprotein3.4.23.160.504
4djqM86Pol polyprotein/0.504
4hdpG52Gag-Pol polyprotein3.4.23.160.504
1ffi2NCGag-Pol polyprotein3.4.23.160.503
2qnnQN1Gag-Pol polyprotein3.4.23.160.503
2rkfAB1Pol protein/0.503
4djr0KJPol polyprotein/0.503
4njsG08Protease/0.503
2bpy3INGag-Pol polyprotein3.4.23.160.502
3nls016Gag-Pol polyprotein3.4.23.160.502
1ivp1ZKGag-Pol polyprotein/0.501
2f80017Gag-Pol polyprotein3.4.23.160.501
3bgbLJGGag-Pol polyprotein3.4.23.160.501
1hiv1ZKGag-Pol polyprotein/0.500
2idw017Protease/0.500
3oxxDR7Gag-Pol polyprotein3.4.23.160.500
2nmyROCProtease/0.499
2qi3MZ5Gag-Pol polyprotein/0.499
2qnqQN3Gag-Pol polyprotein3.4.23.160.499
3jvwDMPGag-Pol polyprotein3.4.23.160.499
2p3b3TLV-1 PROTEASE protein/0.498
2p3b3TLV-1 protease/0.498
2qi7MZ9Gag-Pol polyprotein/0.498
3em4DR7Gag-Pol polyprotein3.4.23.160.498
2i4dQFIProtease/0.497
3kfn3TLGag-Pol polyprotein/0.497
3nu9478Gag-Pol polyprotein3.4.23.160.497
3vfa031Gag-Pol polyprotein3.4.23.160.497
1fej2NCGag-Pol polyprotein3.4.23.160.496
2uy0HV1Gag-Pol polyprotein3.4.23.160.496
3em6017Gag-Pol polyprotein3.4.23.160.496
3lzu017Gag-Pol polyprotein3.4.23.160.496
3sa6F71Protease/0.496
1d4sTPVGag-Pol polyprotein3.4.23.160.495
1d4yTPVGag-Pol polyprotein3.4.23.160.495
2f8g017Gag-Pol polyprotein3.4.23.160.495
2hb3GRLProtease/0.495
3ndtROCGag-Pol polyprotein3.4.23.160.495
3sa9A68Protease/0.495
3sabF78Protease/0.495
4hegG52Gag-Pol polyprotein3.4.23.160.495
2qi5MZ7Gag-Pol polyprotein/0.494
3cktYDPGag-Pol polyprotein3.4.23.160.494
3ggaGGWGag-Pol polyprotein/0.494
3kf03TLGag-Pol polyprotein/0.494
3kfs3TLGag-Pol polyprotein/0.494
3nu4478Gag-Pol polyprotein3.4.23.160.494
3nwq2NCGag-Pol polyprotein3.4.23.160.494
3sa4F72Protease/0.494
2aoe0Q4Gag-Pol polyprotein3.4.23.160.493
2uxzHI1Gag-Pol polyprotein3.4.23.160.493
3gi6D78Gag-Pol polyprotein/0.493
3o9cK20Pol polyprotein/0.493
1hxbROCGag-Pol polyprotein3.4.23.160.492
1wbmBLLPol protein/0.492
2fxdDR7Pol polyprotein/0.492
3d1xROCGag-Pol polyprotein3.4.23.160.492
3ttp017Gag-Pol polyprotein3.4.23.160.492
3ucb017Gag-Pol polyprotein/0.492
4djpM73Pol polyprotein/0.492
1idb0DOGag-Pol polyprotein/0.491
1iiq0ZRGag-Pol polyprotein3.4.23.160.491
2hc0AB2Protease/0.491
2qd7065Gag-Pol polyprotein3.4.23.160.491
3sa323XProtease/0.491
3saa77FProtease/0.491
3sacAF8Protease/0.491
1k1u0Q4Gag-Pol polyprotein3.4.23.160.490
1rl8RITGag-Pol polyprotein3.4.23.160.490
1w5xBE5Gag-Pol polyprotein3.4.23.160.490
3bva2NCGag-Pol polyprotein3.4.23.160.490
3djkG55Gag-Pol polyprotein3.4.23.160.490
3kddJZQGag-Pol polyprotein3.4.23.160.490
4a6cQG9Gag-Pol polyprotein3.4.23.160.490
4q1y017Gag-Pol polyprotein3.4.23.160.490
1dw60Q4Gag-Pol polyprotein3.4.23.160.489
1hvlA76Gag-Pol polyprotein/0.489
1hvsA77Gag-Pol polyprotein/0.489
1tcxIM1Gag-Pol polyprotein3.4.23.160.489
2bpz3INGag-Pol polyprotein3.4.23.160.489
2q5kAB1Protease/0.489
1ida0POGag-Pol polyprotein3.4.23.470.488
3liqE14Protease/0.488
3oxcROCProtease/0.488
1sh9RITGag-Pol polyprotein3.4.23.160.487
2aidTHKGag-Pol polyprotein3.4.23.160.487
2f3kRO1Protease/0.487
2qci065Gag-Pol polyprotein3.4.23.160.487
3cyxROCGag-Pol polyprotein3.4.23.160.487
2bpw1INGag-Pol polyprotein3.4.23.160.486
3ekv478Gag-Pol polyprotein3.4.23.160.486
3el9DR7Gag-Pol polyprotein3.4.23.160.486
3gi4K60Gag-Pol polyprotein/0.486
3sa5A69Protease/0.486
3sa8K83Protease/0.486
3t3c017Gag-Pol polyprotein3.4.23.160.486
2p3c3TLProtease/0.485
4qgiROCGag-Pol polyprotein3.4.23.160.485
1fg80Q4Gag-Pol polyprotein3.4.23.160.484
2pqzG0GGag-Pol polyprotein3.4.23.160.484
3dckKVIProtease/0.484
3s43478Protease/0.484
4njt017Protease/0.484
1d4lPI9Gag-Pol polyprotein3.4.23.160.483
1k2b0Q4Gag-Pol polyprotein3.4.23.160.483
1xl5190Gag-Pol polyprotein3.4.23.160.483
1bv7XV6Gag-Pol polyprotein3.4.23.160.482
1wbk568Pol protein/0.482
2i4uDJRProtease/0.482
3el4ROCGag-Pol polyprotein3.4.23.160.482
3kfr3TLGag-Pol polyprotein/0.482
2qnpQN2Gag-Pol polyprotein3.4.23.160.481
3k4vROCGag-Pol polyprotein3.4.23.160.481
3lzv017Gag-Pol polyprotein3.4.23.160.481
1ec0BEDGag-Pol polyprotein3.4.23.160.480
1hshMK1Gag-Pol polyprotein/0.480
3nuo478Gag-Pol polyprotein3.4.23.160.480
1a9mU0EGag-Pol polyprotein/0.479
1t3r017Gag-Pol polyprotein3.4.23.160.479
1w5yBE6Gag-Pol polyprotein3.4.23.160.479
4njuTPVProtease/0.479
1hviA77Protease/0.478
1qbu846Gag-Pol polyprotein3.4.23.160.478
1w5vBE3Gag-Pol polyprotein3.4.23.160.478
2wl05AHGag-Pol polyprotein/0.478
3jvy017Gag-Pol polyprotein3.4.23.160.478
3o9bK2APol polyprotein/0.478
1hsgMK1Gag-Pol polyprotein/0.477
1sdvMK1Gag-Pol polyprotein3.4.23.160.477
2nnpROCProtease/0.477
2qhcAB1Protease/0.477
4i8zG08Gag-Pol polyprotein3.4.23.160.477
1hpoUNIGag-Pol polyprotein3.4.23.160.476
1hvkA79Gag-Pol polyprotein/0.476
1jld0PPGag-Pol polyprotein/0.476
1meuDMPGag-Pol polyprotein3.4.23.160.476
2p3d3TLProtease/0.476
3cyw017Gag-Pol polyprotein3.4.23.160.476
3ufnROCGag-Pol polyprotein/0.476
7upjINUGag-Pol polyprotein3.4.23.160.476
1d4iBEGGag-Pol polyprotein3.4.23.160.475
3bgcLJHGag-Pol polyprotein3.4.23.160.475
3pwrROCGag-Pol polyprotein3.4.23.160.475
4dqc017Gag-Pol polyprotein/0.475
1a8k0Q4Gag-Pol polyprotein3.4.23.160.474
1ebyBEBGag-Pol polyprotein3.4.23.160.474
1ebzBECGag-Pol polyprotein3.4.23.160.474
1ec1BEEGag-Pol polyprotein3.4.23.160.474
2qhyMZ1Gag-Pol polyprotein/0.474
2qhzMZ2Gag-Pol polyprotein/0.474
3qaaG04Gag-Pol polyprotein3.4.23.160.474
1c6zROCProtease/0.473
1hiiC20Gag-Pol polyprotein/0.473
1sdtMK1Gag-Pol polyprotein3.4.23.160.473
1z1hHBBGag-Pol polyprotein3.4.23.160.473
1zsr0ZTGag-Pol polyprotein3.4.23.160.473
3gi5K62Gag-Pol polyprotein/0.473
3oxv478Gag-Pol polyprotein3.4.23.160.473
3tog079Gag-Pol polyprotein2.7.7.490.473
1mesDMPGag-Pol polyprotein3.4.23.160.472
2qi6MZ8Gag-Pol polyprotein/0.472
3ekyDR7Gag-Pol polyprotein3.4.23.160.472
4dqe017Gag-Pol polyprotein/0.472
1bdrIM1Gag-Pol polyprotein3.4.23.160.471
1t7kBH0Gag-Pol polyprotein3.4.23.160.471
3el1DR7Gag-Pol polyprotein3.4.23.160.471
4dfg0JVGag-Pol polyprotein3.4.23.160.471
2q3kMUWGag-Pol polyprotein/0.470
1bai0Q4Gag-Pro polyprotein/0.469
1g2kNM1Gag-Pol polyprotein3.4.23.160.469
1sguMK1Gag-Pol polyprotein3.4.23.160.469
3nwxKVSGag-Pol polyprotein3.4.23.160.469
3o9eA60Pol polyprotein/0.469
2p3a3TLPol protein/0.468
2r3tG4GGag-Pol polyprotein3.4.23.160.468
3lzs017Gag-Pol polyprotein3.4.23.160.468
3nu5478Gag-Pol polyprotein3.4.23.160.468
3o9fK2DGag-Pol polyprotein/0.468
3o9gF53Gag-Pol polyprotein/0.468
3o9iA61Gag-Pol polyprotein/0.468
3vf7031Gag-Pol polyprotein3.4.23.160.468
1a940Q4Gag-Pol polyprotein3.4.23.160.467
1daz0Q4Gag-Pol polyprotein3.4.23.160.467
1ebwBEIGag-Pol polyprotein3.4.23.160.467
1hosPHPGag-Pol polyprotein/0.467
1qbsDMPGag-Pol polyprotein3.4.23.160.467
1z1rHBHGag-Pol polyprotein3.4.23.160.467
2b60RITPol polyprotein/0.467
3em3478Gag-Pol polyprotein3.4.23.160.467
3o9dK19Pol polyprotein/0.467
3qrsNK8Gag-Pol polyprotein3.4.23.160.467
3s54017Protease/0.467
4dqf017Gag-Pol polyprotein/0.467
1b6kPI5Gag-Pol polyprotein3.4.23.160.466
1n49RITGag-Pol polyprotein3.4.23.160.466
1sbgIM1Gag-Pol polyprotein/0.466
2r38G4GGag-Pol polyprotein3.4.23.160.466
3d1z017Gag-Pol polyprotein3.4.23.160.466
3el51UNGag-Pol polyprotein/0.466
3qp0NI8Gag-Pol polyprotein3.4.23.160.466
3s56ROCProtease/0.466
4k4p3TLGag-Pol polyprotein/0.466
2b7zMK1Gag-Pol polyprotein/0.465
2f81017Gag-Pol polyprotein3.4.23.160.465
1d4jMSCGag-Pol polyprotein3.4.23.160.464
1odyLP1Gag-Pol polyprotein3.4.23.160.464
1ohr1UNV-1 PROTEASE protein/0.464
2qi4MZ6Gag-Pol polyprotein/0.464
2r43G3GGag-Pol polyprotein3.4.23.160.464
3nuj478Gag-Pol polyprotein3.4.23.160.464
3el01UNGag-Pol polyprotein3.4.23.160.463
3qbfJHGGag-Pol polyprotein3.4.23.160.463
1qbrXV6Gag-Pol polyprotein3.4.23.160.462
1sduMK1Gag-Pol polyprotein3.4.23.160.462
1t7j478Gag-Pol polyprotein3.4.23.160.462
2o4pTPVProtease/0.462
3livE16Protease/0.462
1b6pPI7Gag-Pol polyprotein3.4.23.160.461
1bwaXV6Gag-Pol polyprotein3.4.23.160.461
2bbbHH1Gag-Pol polyprotein3.4.23.160.461
2q54MU1Protease/0.461
3lixE17Protease/0.461
3nu3478Gag-Pol polyprotein3.4.23.160.461
3oy4017Gag-Pol polyprotein3.4.23.160.461
1a8g2Z4Gag-Pol polyprotein3.4.23.160.460
1hpv478Gag-Pol polyprotein/0.460
1iziQ50Gag-Pol polyprotein3.4.23.160.460
9hvp0E9Gag-Pol polyprotein/0.460
1d4kPI8Gag-Pol polyprotein3.4.23.160.459
1muiAB1Protease/0.459
1npvL27Gag-Pol polyprotein3.4.23.160.459
2bb9AKCGag-Pol polyprotein3.4.23.160.459
2hs1017Protease/0.459
2i0dMUTProtease/0.459
3fx5KNIGag-Pol polyprotein3.4.23.160.459
1ajvNMBGag-Pol polyprotein3.4.23.160.458
1c6x3INProtease/0.458
1ivq0PXGag-Pol polyprotein/0.458
3oxw017Gag-Pol polyprotein3.4.23.160.458
3so9017Pol protein/0.458
2cej1AHPol protein/0.457
2hs2017Protease/0.457
4dqh017Gag-Pol polyprotein/0.457
1npa3NHGag-Pol polyprotein3.4.23.160.456
1npwLGZGag-Pol polyprotein3.4.23.160.456
2qak1UNGag-Pol polyprotein3.4.23.160.456
2qi0MZ3Gag-Pol polyprotein/0.456
3mws017Pol protein/0.456
3qroNK9Gag-Pol polyprotein3.4.23.160.456
1b6mPI6Gag-Pol polyprotein3.4.23.160.455
1g35AHFGag-Pol polyprotein3.4.23.160.455
1hwr216Gag-Pol polyprotein3.4.23.160.455
1odw0E8Gag-Pol polyprotein3.4.23.160.455
3aidARQGag-Pol polyprotein3.4.23.160.455
3i7eDJRGag-Pol polyprotein/0.455
1fff0Q4Gag-Pol polyprotein3.4.23.160.454
1izhQ50Protease/0.454
2q641UNGag-Pol polyprotein3.4.23.160.454
2z4o065Gag-Pol polyprotein3.4.23.160.454
3mxdK53Gag-Pol polyprotein3.4.23.160.454
3nu6478Gag-Pol polyprotein3.4.23.160.454
1ebk0Q4Gag-Pol polyprotein3.4.23.160.453
1mtrPI6Gag-Pol polyprotein3.4.23.160.453
2pyn1UNGag-Pol polyprotein3.4.23.160.453
3qn8NI7Gag-Pol polyprotein3.4.23.160.453
3qrmNK7Gag-Pol polyprotein3.4.23.160.453
1hpxKNIGag-Pol polyprotein/0.452
1msmJE2Gag-Pol polyprotein3.4.23.160.452
1proA88Gag-Pol polyprotein/0.452
1sivPSIGag-Pol polyprotein/0.452
2avvMK1Gag-Pol polyprotein3.4.23.160.452
2qi1MZ4Gag-Pol polyprotein/0.452
3d20017Gag-Pol polyprotein3.4.23.160.452
3i6oGR6Gag-Pol polyprotein3.4.23.160.452
1kzkJE2Gag-Pol polyprotein3.4.23.160.451
2fleAIProtease/0.451
2r5pMK1Gag-Pol polyprotein/0.451
2r5q1UNGag-Pol polyprotein/0.451
3ggu017Gag-Pol polyprotein3.4.23.160.451
3o9aK14Pol polyprotein/0.451
3pwm017Gag-Pol polyprotein3.4.23.160.451
4dqb017Gag-Pol polyprotein/0.451
3litE15Protease/0.450
3wsjMK1Protease/0.450
1hvrXK2Gag-Pol polyprotein/0.449
2pwcG3GGag-Pol polyprotein3.4.23.160.449
2pym1UNGag-Pol polyprotein3.4.23.160.449
1bv9XV6Gag-Pol polyprotein3.4.23.160.448
1d4hBEHGag-Pol polyprotein3.4.23.160.448
1hihC20Gag-Pol polyprotein/0.448
2avsMK1Gag-Pol polyprotein3.4.23.160.448
1qbt146Gag-Pol polyprotein3.4.23.160.447
3ec0GRLGag-Pol polyprotein3.4.23.470.447
4gb20LQGag-Pol polyprotein2.7.7.490.447
2psuMUUProtease/0.446
2r3wG3GGag-Pol polyprotein3.4.23.160.445
3upjU03Gag-Pol polyprotein/0.444
3o99K13Pol polyprotein/0.443
1zsf0ZSGag-Pol polyprotein3.4.23.160.442
3o9hK2EGag-Pol polyprotein/0.442
4hla017Gag-Pol polyprotein3.4.23.160.441
1c70L75Protease/0.440
2z54AB1Gag-Pol polyprotein3.4.23.160.440
3bvb017Gag-Pol polyprotein3.4.23.160.440
3slz3TLPutative gag-pro-pol polyprotein/0.440