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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3tp0FO5HTH-type transcriptional regulator EthR

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3tp0FO5HTH-type transcriptional regulator EthR/1.000
3o8gO8GHTH-type transcriptional regulator EthR/0.662
3o8hO8HHTH-type transcriptional regulator EthR/0.662
3q0uLL3HTH-type transcriptional regulator EthR/0.640
3sfi3SFHTH-type transcriptional regulator EthR/0.634
3q0vLL4HTH-type transcriptional regulator EthR/0.622
3g1mRF3HTH-type transcriptional regulator EthR/0.555
4dw60MNHTH-type transcriptional regulator EthR/0.521
3g1oRF1HTH-type transcriptional regulator EthR/0.486
3g1lRF2HTH-type transcriptional regulator EthR/0.470
5dbgNADIridoid synthase1.3.1.990.460
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.455
2jfhLK1UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.448
2vbpVB1Isopenicillin N synthase1.21.3.10.447
2yjxYJXHeat shock protein HSP 90-alpha/0.446
2ykbYKBHeat shock protein HSP 90-alpha/0.444
4jbtASDCytochrome P450 monooxygenase/0.443
4u2lSFDCholesterol oxidase1.1.3.60.443
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.440
4iaq2GM5-hydroxytryptamine receptor 1B/0.440