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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/1.000
4i421HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.637
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.636
4qii2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.571
4i521HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.546
4qij1HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.537
1q51CAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.511
2uzfCAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.505
3gw9VNILanosterol 14-alpha-demethylase/0.476
5jscFADPutative acyl-CoA dehydrogenase/0.464
1ey3DAKEnoyl-CoA hydratase, mitochondrial4.2.1.170.451
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.442
4g3jVNTLanosterol 14-alpha-demethylase/0.441
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440