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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3t7sSAMUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3t7sSAMUncharacterized protein/1.000
3kkzSAMUncharacterized protein/0.617
3sxjSAMPutative methyltransferase/0.614
3t0iSAHPutative methyltransferase/0.519
3t7tSAHUncharacterized protein/0.518
4eb7PLPCysteine desulfurase IscS 2/0.474
3hyoADPPyridoxal kinase/0.464
3d91REMRenin3.4.23.150.462
1x1aSAMC-20 methyltransferase/0.457
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.455
3nsh957Beta-secretase 13.4.23.460.455
4i0i957Beta-secretase 13.4.23.460.455
4j4nD44Peptidylprolyl isomerase/0.453
1xe65FPPlasmepsin-23.4.23.390.450
1ex75GPGuanylate kinase2.7.4.80.449
4nv14TGFormyl transferase/0.448
2g1r3IGRenin3.4.23.150.447
4iv8SAMPhosphoethanolamine N-methyltransferase,putative/0.447
4qtuSAM18S rRNA (guanine(1575)-N(7))-methyltransferase/0.445
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.444
1xe55FEPlasmepsin-23.4.23.390.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.442
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.441
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4eb5PLPCysteine desulfurase IscS 2/0.441