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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3s79ASDAromatase1.14.14.14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3s79ASDAromatase1.14.14.141.000
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.546
4k9v6AWCytochrome P450 3A4/0.509
3tjsD0RCytochrome P450 3A4/0.505
3nxuRITCytochrome P450 3A4/0.498
3wecAUICytochrome P450/0.498
4enhFVXCholesterol 24-hydroxylase/0.493
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.491
4uymVOR14-alpha sterol demethylase Cyp51B/0.490
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.485
5hs1VORLanosterol 14-alpha demethylase/0.484
3ibdCPZCytochrome P450 2B61.14.130.481
3tk3CPZCytochrome P450 2B41.14.14.10.473
3p3zP3ZPutative cytochrome P450/0.472
4tuvCPZCytochrome P450 1191.140.472
2j0dERYCytochrome P450 3A4/0.469
4ejh0QACytochrome P450 2A131.14.14.10.468
1dz6CAMCamphor 5-monooxygenase1.14.15.10.465
3mdmFJZCholesterol 24-hydroxylase/0.463
1jioDEB6-deoxyerythronolide B hydroxylase/0.459
3p99LNPLanosterol 14-alpha-demethylase/0.459
3ua108YCytochrome P450 3A4/0.459
1phgMYTCamphor 5-monooxygenase1.14.15.10.458
1suoCPZCytochrome P450 2B41.14.14.10.458
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
2vn0TDZCytochrome P450 2C8/0.456
1m13HYFNuclear receptor subfamily 1 group I member 2/0.454
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
3nr4PYVAbscisic acid receptor PYL2/0.454
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2cppCAMCamphor 5-monooxygenase1.14.15.10.453
3t3q9PLCytochrome P450 2A61.14.130.453
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.451
4cp4CAMCamphor 5-monooxygenase1.14.15.10.451
3a1l2CCCytochrome P450/0.450
4ejgNCTCytochrome P450 2A131.14.14.10.450
1iwjCAMCamphor 5-monooxygenase1.14.15.10.448
3t3r9PLCytochrome P450 2A61.14.130.448
4g3jVNTLanosterol 14-alpha-demethylase/0.447
3fwjCAMCamphor 5-monooxygenase1.14.15.10.446
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1t85CAMCamphor 5-monooxygenase1.14.15.10.444
1uyuCAMCamphor 5-monooxygenase1.14.15.10.444
3l63CAMCamphor 5-monooxygenase1.14.15.10.444
1t88CAMCamphor 5-monooxygenase1.14.15.10.443
2a1nCAMCamphor 5-monooxygenase1.14.15.10.443
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1nooCAHCamphor 5-monooxygenase1.14.15.10.442
4l49CAMCamphor 5-monooxygenase1.14.15.10.442
2qbnCAMCamphor 5-monooxygenase1.14.15.10.441
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.440
5cp4CAMCamphor 5-monooxygenase1.14.15.10.440