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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.711
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.663
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.658
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.643
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.637
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.637
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.630
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.626
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.625
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.624
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.621
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.614
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.608
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.601
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.601
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.598
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.598
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.585
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.580
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.466
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.462
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.446