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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3poz03PEpidermal growth factor receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3poz03PEpidermal growth factor receptor2.7.10.11.000
3w32W32Epidermal growth factor receptor2.7.10.10.674
3w33W19Epidermal growth factor receptor2.7.10.10.662
1xkkFMMEpidermal growth factor receptor2.7.10.10.583
3w2sW2REpidermal growth factor receptor2.7.10.10.573
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.542
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.541
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.524
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.523
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.521
3vs3VSETyrosine-protein kinase HCK2.7.10.20.513
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.506
4i22IREEpidermal growth factor receptor2.7.10.10.500
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.498
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.495
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.494
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.494
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.492
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.482
3vs1VSATyrosine-protein kinase HCK2.7.10.20.481
3w2rW2REpidermal growth factor receptor2.7.10.10.480
4hgs15GCasein kinase I isoform gamma-32.7.11.10.478
3vt7VDXVitamin D3 receptor/0.477
3vt9YI4Vitamin D3 receptor/0.476
3ogqAB1Pol polyprotein/0.474
1jipKTN6-deoxyerythronolide B hydroxylase/0.473
2wotZZGTGF-beta receptor type-12.7.11.300.473
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.471
4nxuADPMitochondrial dynamics protein MID51/0.469
2ca0PXICytochrome P450 monooxygenase PikC/0.467
2po7CHDFerrochelatase, mitochondrial4.99.1.10.466
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.465
3vryB43Tyrosine-protein kinase HCK2.7.10.20.462
4id71G0Activated CDC42 kinase 1/0.461
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.460
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.459
1jioDEB6-deoxyerythronolide B hydroxylase/0.457
1yb5NAPQuinone oxidoreductase1.6.5.50.457
1k6pXN3Gag-Pol polyprotein3.4.23.160.456
2pobGW4Peroxisome proliferator-activated receptor gamma/0.456
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.456
2om9AJAPeroxisome proliferator-activated receptor gamma/0.454
3tqhNDPQuinone oxidoreductase/0.454
1u54ACPActivated CDC42 kinase 1/0.453
2hw2RFPRifampin ADP-ribosyl transferase/0.453
4hjoAQ4Epidermal growth factor receptor2.7.10.10.453
4riyADPEpidermal growth factor receptor2.7.10.10.453
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.452
2vn0TDZCytochrome P450 2C8/0.452
3hv5R24Mitogen-activated protein kinase 14/0.452
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.452
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.452
4xldBRLPeroxisome proliferator-activated receptor gamma/0.452
1ie8KH1Vitamin D3 receptor/0.451
4wkqIREEpidermal growth factor receptor2.7.10.10.451
1rv1IMZE3 ubiquitin-protein ligase Mdm26.3.20.450
1y0s331Peroxisome proliferator-activated receptor delta/0.450
2q5p241Peroxisome proliferator-activated receptor gamma/0.450
3vt8YI3Vitamin D3 receptor/0.450
4nxwADPMitochondrial dynamics protein MID51/0.450
4o2bLOCTubulin beta-2B chain/0.450
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1k6tXN1Gag-Pol polyprotein3.4.23.160.449
3zuyTCHTransporter/0.449
4b7dQLECytochrome P450 monooxygenase PikC/0.449
4b7sQLECytochrome P450 monooxygenase PikC/0.449
4k2xFADPolyketide oxygenase/hydroxylase/0.449
4nka2K7Fibroblast growth factor receptor 1/0.449
4xgxADPFAD:protein FMN transferase/0.449
2w2lNADD-mandelate dehydrogenase/0.448
3k4nFADPyranose 2-oxidase/0.448
3rj5NADAlcohol dehydrogenase1.1.1.10.448
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.447
1s0zEB1Vitamin D3 receptor/0.447
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.447
1u4dDBQActivated CDC42 kinase 1/0.446
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.446
2znq401Peroxisome proliferator-activated receptor delta/0.446
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4a6bQG8Gag-Pol polyprotein3.4.23.160.446
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.446
1kkq471Peroxisome proliferator-activated receptor alpha/0.445
2p33J07Mitogen-activated protein kinase 102.7.11.240.445
2p4yC03Peroxisome proliferator-activated receptor gamma/0.445
3gw9VNILanosterol 14-alpha-demethylase/0.445
4fhi0S4Vitamin D3 receptor A/0.445
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
5fkmTDCTetracycline repressor protein class D/0.445
1tw4CHDFatty acid-binding protein, liver/0.444
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.444
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.444
2c6hPXICytochrome P450 monooxygenase PikC/0.444
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.444
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.444
3w0yDS4Vitamin D3 receptor/0.444
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.443
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
2npaMMBPeroxisome proliferator-activated receptor alpha/0.443
3v9v21LPeroxisome proliferator-activated receptor gamma/0.443
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.443
4q73FADBifunctional protein PutA/0.443
1fm9570Peroxisome proliferator-activated receptor gamma/0.442
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.442
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.442
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.442
3vspEK8Peroxisome proliferator-activated receptor gamma/0.442
3w5rLOAVitamin D3 receptor/0.442
4aa0AA0Mitogen-activated protein kinase 14/0.442
4i3wNADAldehyde dehydrogenase (NAD+)/0.442
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.442
5k2aZMAAdenosine receptor A2a/0.442
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.441
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.441
2izrBRKCasein kinase I isoform gamma-32.7.11.10.441
2jn3JN3Fatty acid-binding protein, liver/0.441
3frqERYErythromycin resistance repressor protein/0.441
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
5itzLOCTubulin beta-2B chain/0.441
1sn5T3Transthyretin/0.440
1zhwHC2Oxysterol-binding protein homolog 4/0.440
2harOCCVitamin D3 receptor/0.440
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.440