sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.533 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.532 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.505 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.501 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.493 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.493 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.483 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 3fkn | FKN | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.460 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.459 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.455 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 3qwi | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.452 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.451 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3lth | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.448 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.448 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.447 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.446 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.446 | |
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.444 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.444 | |
| 2jfz | 003 | Glutamate racemase | / | 0.443 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.443 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 5doz | NDP | JamJ | / | 0.440 |