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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3oriAGSSerine/threonine protein kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3oriAGSSerine/threonine protein kinase/1.000
3oroAGSSerine/threonine protein kinase/0.528
3ormAGSSerine/threonine protein kinase/0.511
5dnrATPAurora kinase A2.7.11.10.493
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.484
4lfiGNPCasein kinase II subunit alpha2.7.11.10.480
3orpAGSSerine/threonine protein kinase/0.475
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.469
3c4zADPRhodopsin kinase/0.469
1pmn984Mitogen-activated protein kinase 102.7.11.240.468
3c4wATPRhodopsin kinase/0.467
1jnkANPMitogen-activated protein kinase 102.7.11.240.466
3t8oATPRhodopsin kinase/0.466
3ortAGSSerine/threonine protein kinase/0.464
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.461
2j0lANPFocal adhesion kinase 12.7.10.20.460
4deeADPAurora kinase A2.7.11.10.460
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.458
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.454
4qnyANPMitogen activated protein kinase, putative/0.454
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.452
2qo7ANPEphrin type-A receptor 32.7.10.10.452
5cnoANPEpidermal growth factor receptor2.7.10.10.452
5dosATPAurora kinase A2.7.11.10.450
1dawANPCasein kinase II subunit alpha2.7.11.10.449
4k33ACPFibroblast growth factor receptor 32.7.10.10.449
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.447
4jbpYPHAurora kinase A2.7.11.10.447
1dayGNPCasein kinase II subunit alpha2.7.11.10.444
2xrwANPMitogen-activated protein kinase 82.7.11.240.444
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.444
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.443
4bbe3O4Tyrosine-protein kinase JAK2/0.443
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.442
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.441
4ysjADPCalmodulin-like domain protein kinase/0.441