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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3nxyD2HDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3nxyD2HDihydrofolate reductase1.5.1.31.000
3nxvD2FDihydrofolate reductase1.5.1.30.710
3nxrD2DDihydrofolate reductase1.5.1.30.642
4ddrMMVDihydrofolate reductase1.5.1.30.607
3nxoD2BDihydrofolate reductase1.5.1.30.602
1s3wTQTDihydrofolate reductase1.5.1.30.596
3nxtD2EDihydrofolate reductase1.5.1.30.585
4kfj1R0Dihydrofolate reductase1.5.1.30.585
2w3aTOPDihydrofolate reductase1.5.1.30.584
3oafOAGDihydrofolate reductase1.5.1.30.581
4kak06UDihydrofolate reductase1.5.1.30.578
4qjcIXEDihydrofolate reductase1.5.1.30.573
3ntz3TZDihydrofolate reductase1.5.1.30.569
1dlrMXADihydrofolate reductase1.5.1.30.568
3k47D09Dihydrofolate reductase1.5.1.30.563
4g95OAGDihydrofolate reductase1.5.1.30.550
4kbn25UDihydrofolate reductase1.5.1.30.537
1pd8CO4Dihydrofolate reductase1.5.1.30.531
4kd79DRDihydrofolate reductase1.5.1.30.528
1bozPRDDihydrofolate reductase1.5.1.30.527
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.518
1pd9CO4Dihydrofolate reductase1.5.1.30.506
1hfrMOTDihydrofolate reductase1.5.1.30.498
1cd2FOLDihydrofolate reductase1.5.1.30.497
1kmsLIHDihydrofolate reductase1.5.1.30.496
3qly55VUncharacterized protein/0.496
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.494
1u72MTXDihydrofolate reductase1.5.1.30.491
1hfpMOTDihydrofolate reductase1.5.1.30.489
2w3mFOLDihydrofolate reductase1.5.1.30.489
4kebFOLDihydrofolate reductase1.5.1.30.486
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.485
1dr4HBIDihydrofolate reductase1.5.1.30.482
3cseN22Uncharacterized protein/0.482
4m6kFOLDihydrofolate reductase1.5.1.30.481
3eek53SUncharacterized protein/0.480
4h9814QUncharacterized protein/0.478
3gi2GHWDihydrofolate reductase1.5.1.30.477
4h9753SDihydrofolate reductase1.5.1.30.477
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.474
1dr3HBIDihydrofolate reductase1.5.1.30.472
1hfqMOTDihydrofolate reductase1.5.1.30.471
1mvsDTMDihydrofolate reductase1.5.1.30.471
3eem53VUncharacterized protein/0.468
1ohjCOPDihydrofolate reductase1.5.1.30.466
3s3vTOPDihydrofolate reductase1.5.1.30.466
3eej53RUncharacterized protein/0.465
1vj3TABDihydrofolate reductase1.5.1.30.464
3ghvGHCDihydrofolate reductase1.5.1.30.464
3nmpPYVAbscisic acid receptor PYL2/0.462
4m6l21VDihydrofolate reductase1.5.1.30.462
3gyf51PDihydrofolate reductase1.5.1.30.460
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.460
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4iarERM5-hydroxytryptamine receptor 1B/0.459
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.458
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
3s41S41Glucokinase2.7.1.20.456
1aoeGW3Dihydrofolate reductase1.5.1.30.455
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.455
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.454
4ixfIXFDihydrofolate reductase1.5.1.30.454
5bt42LOBromodomain-containing protein 4/0.454
4h9506UDihydrofolate reductase1.5.1.30.453
3qlxQLRUncharacterized protein/0.452
3up3XCAaceDAF-12/0.452
1e26GPBDihydrofolate reductase1.5.1.30.451
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2pnuENMAndrogen receptor/0.451
4qa0SHHHistone deacetylase 83.5.1.980.451
1pkfEPDEpothilone C/D epoxidase1.140.450
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
4qa2SHHHistone deacetylase 83.5.1.980.450
2z7gEH9Adenosine deaminase3.5.4.40.448
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.447
1jomFFODihydrofolate reductase1.5.1.30.446
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3nhrRZWRibosyldihydronicotinamide dehydrogenase [quinone]/0.445
4dhyS41Glucokinase2.7.1.20.445
4ej1FOLDihydrofolate reductase1.5.1.30.445
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
1klkPMDDihydrofolate reductase1.5.1.30.444
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
1drfFOLDihydrofolate reductase1.5.1.30.443
1re0AFBADP-ribosylation factor 1/0.443
1re0AFBARF guanine-nucleotide exchange factor 1/0.443
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3qlzQLZUncharacterized protein/0.443
4bfyZVYPantothenate kinase2.7.1.330.443
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4ixeIXEDihydrofolate reductase1.5.1.30.442
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.441
2cd2FOLDihydrofolate reductase1.5.1.30.441
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3eel53TUncharacterized protein/0.441
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4jlj1NMDeoxycytidine kinase2.7.1.740.441
3g70A5TRenin3.4.23.150.440
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.440