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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3n8xNIMProstaglandin G/H synthase 11.14.99.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3n8xNIMProstaglandin G/H synthase 11.14.99.11.000
3rr3FLRProstaglandin G/H synthase 21.14.99.10.636
1q4gBFLProstaglandin G/H synthase 11.14.99.10.633
1eqhFLPProstaglandin G/H synthase 11.14.99.10.622
3n8wFLPProstaglandin G/H synthase 11.14.99.10.622
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.612
1eqgIBPProstaglandin G/H synthase 11.14.99.10.611
3q7dNPXProstaglandin G/H synthase 21.14.99.10.598
3ln1CELProstaglandin G/H synthase 21.14.99.10.596
3ntgD72Prostaglandin G/H synthase 21.14.99.10.596
4coxIMNProstaglandin G/H synthase 21.14.99.10.596
2aylFLPProstaglandin G/H synthase 11.14.99.10.594
2oyuIMSProstaglandin G/H synthase 11.14.99.10.588
3mqe416Prostaglandin G/H synthase 21.14.99.10.586
4otyLURProstaglandin G/H synthase 21.14.99.10.582
1ht834CProstaglandin G/H synthase 11.14.99.10.579
4ph9IBPProstaglandin G/H synthase 21.14.99.10.576
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.574
4rrxLURProstaglandin G/H synthase 21.14.99.10.573
3pghFLPProstaglandin G/H synthase 21.14.99.10.572
3kk6CELProstaglandin G/H synthase 11.14.99.10.562
3n8zFLPProstaglandin G/H synthase 11.14.99.10.562
5ikrID8Prostaglandin G/H synthase 21.14.99.10.556
4rrwLURProstaglandin G/H synthase 21.14.99.10.555
4rrzLURProstaglandin G/H synthase 21.14.99.10.555
1pxxDIFProstaglandin G/H synthase 21.14.99.10.543
1ht5FL2Prostaglandin G/H synthase 11.14.99.10.539
5ikqJMSProstaglandin G/H synthase 21.14.99.10.538
6coxS58Prostaglandin G/H synthase 21.14.99.10.528
1cx2S58Prostaglandin G/H synthase 21.14.99.10.524
4m10ICDProstaglandin G/H synthase 21.14.99.10.523
5iktTLFProstaglandin G/H synthase 21.14.99.10.516
3n8yDIFProstaglandin G/H synthase 11.14.99.10.506
3ln052BProstaglandin G/H synthase 21.14.99.10.500
3sn6P0GBeta-2 adrenergic receptor/0.489
3mnrSD1Heat shock protein HSP 90-alpha/0.476
2npaMMBPeroxisome proliferator-activated receptor alpha/0.475
2om9AJAPeroxisome proliferator-activated receptor gamma/0.469
3vt5YI2Vitamin D3 receptor/0.468
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.466
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.464
1uzwCDHIsopenicillin N synthase1.21.3.10.464
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.464
5uviZMAAdenosine receptor A2a/0.464
4zj8SUVOrexin receptor type 1/0.462
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.461
3af0GDPPantothenate kinase2.7.1.330.461
2vcmM11Isopenicillin N synthase1.21.3.10.460
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.460
5k2dZMAAdenosine receptor A2a/0.458
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.457
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.455
1w06W05Isopenicillin N synthase1.21.3.10.454
3qdd94MHeat shock protein HSP 90-alpha/0.453
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.451
2vbpVB1Isopenicillin N synthase1.21.3.10.451
4eajATP5'-AMP-activated protein kinase subunit gamma-1/0.451
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.450
1kqwRTLCellular retinol-binding protein type II/0.449
2znq401Peroxisome proliferator-activated receptor delta/0.449
4ib4ERM5-hydroxytryptamine receptor 2B/0.449
4l0qNADAlcohol dehydrogenase class-3/0.449
5k2bZMAAdenosine receptor A2a/0.449
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.448
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3vrvYSDVitamin D3 receptor/0.448
4bfwZVWPantothenate kinase2.7.1.330.448
4iae1DXAlr2278 protein/0.448
1l8qADPChromosomal replication initiator protein DnaA/0.447
1zdwFLVPrenyltransferase/0.447
2o12FMNChorismate synthase/0.447
3frqERYErythromycin resistance repressor protein/0.446
4a81DXCMajor pollen allergen Bet v 1-A/0.445
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.444
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3vrwYS5Vitamin D3 receptor/0.444
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.443
2ykeYKEHeat shock protein HSP 90-alpha/0.443
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.443
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.443
2lbaCHOFatty acid binding protein 6/0.442
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.442
3uqdATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.442
3vqsJT1Genome polyprotein/0.442
4qzuRTLRetinol-binding protein 2/0.442
3pwhZMAAdenosine receptor A2a/0.442
2vw5BC6ATP-dependent molecular chaperone HSP82/0.441
2ydwWSHBromodomain-containing protein 2/0.441
2ywwATPAspartate carbamoyltransferase regulatory chain/0.441
3af1GDPPantothenate kinase2.7.1.330.441
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.441
3pgqGY3Acetyl-CoA carboxylase/0.441
3qlrNDPDihydrofolate reductase1.5.1.30.441
3vruYS3Vitamin D3 receptor/0.441
4aosNAPSteroid monooxygenase/0.441
4o701QKBromodomain-containing protein 4/0.441
4ww4ADPRuvB-like helicase/0.441
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.441
1h50FMNPentaerythritol tetranitrate reductase/0.440
2bu9HFVIsopenicillin N synthase1.21.3.10.440
3b9lAZZSerum albumin/0.440
4g48PZBMycocyclosin synthase1.14.21.90.440
4ure1PSCyclohexanol dehydrogenase/0.440
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440