sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 1.000 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.662 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.649 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.646 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.638 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.623 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.608 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.600 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.595 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.593 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.592 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.590 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.586 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.583 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.582 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.579 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.576 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.568 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.568 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.564 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.561 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.561 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.556 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.556 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.556 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.555 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.552 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.548 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.547 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.547 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.545 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.543 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.539 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.529 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.526 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.525 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.524 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.522 | |
| 1xuc | PB3 | Collagenase 3 | 3.4.24 | 0.512 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.508 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.507 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.504 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.504 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.489 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.487 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.486 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.485 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.482 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.481 | |
| 2w0d | CGS | Macrophage metalloelastase | 3.4.24.65 | 0.481 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.477 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.474 | |
| 1zs0 | EIN | Neutrophil collagenase | 3.4.24.34 | 0.474 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.465 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.464 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.454 | |
| 1bzs | BSI | Neutrophil collagenase | 3.4.24.34 | 0.453 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.451 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.450 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.448 | |
| 2ow2 | 8MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.448 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.448 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.441 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.440 |