sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3k5e | K5E | Kinesin-like protein KIF11 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3k5e | K5E | Kinesin-like protein KIF11 | / | 1.000 | |
| 1x88 | NAT | Kinesin-like protein KIF11 | / | 0.678 | |
| 2x7c | KZ9 | Kinesin-like protein KIF11 | / | 0.667 | |
| 2ieh | MOY | Kinesin-like protein KIF11 | / | 0.648 | |
| 2fme | 3QC | Kinesin-like protein KIF11 | / | 0.644 | |
| 2x7d | EGB | Kinesin-like protein KIF11 | / | 0.629 | |
| 2x7e | X7E | Kinesin-like protein KIF11 | / | 0.628 | |
| 3k3b | L31 | Kinesin-like protein KIF11 | / | 0.613 | |
| 1q0b | NAT | Kinesin-like protein KIF11 | / | 0.610 | |
| 2q2z | MKK | Kinesin-like protein KIF11 | / | 0.597 | |
| 4bbg | V02 | Kinesin-like protein KIF11 | / | 0.588 | |
| 2xae | 2XA | Kinesin-like protein KIF11 | / | 0.586 | |
| 3ken | ZZD | Kinesin-like protein KIF11 | / | 0.578 | |
| 2g1q | N9H | Kinesin-like protein KIF11 | / | 0.561 | |
| 2wog | ZZD | Kinesin-like protein KIF11 | / | 0.551 | |
| 2x2r | X2O | Kinesin-like protein KIF11 | / | 0.547 | |
| 4a51 | DQ8 | Kinesin-like protein KIF11 | / | 0.546 | |
| 2gm1 | 2AZ | Kinesin-like protein KIF11 | / | 0.533 | |
| 4as7 | 6LX | Kinesin-like protein KIF11 | / | 0.493 | |
| 4a5y | G7X | Kinesin-like protein KIF11 | / | 0.492 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.480 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.477 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.471 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 5aab | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.460 | |
| 3p3c | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.459 | |
| 1m0w | ANP | Glutathione synthetase | 6.3.2.3 | 0.458 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.456 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.456 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.454 | |
| 4cfn | JYM | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.452 | |
| 1iep | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.452 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.451 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.450 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 3rni | 21Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3ddq | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3rjc | 06Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.446 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.445 | |
| 3lfs | A07 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.445 | |
| 4erw | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4o2z | 046 | Mitogen-activated protein kinase | / | 0.445 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.444 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 2d1s | SLU | Luciferin 4-monooxygenase | 1.13.12.7 | 0.443 | |
| 2igy | A2T | Plasmepsin 2 | / | 0.443 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.442 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.442 | |
| 3q8h | AO9 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.442 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4oac | ADP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.442 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 1oi9 | N20 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3wsj | MK1 | Protease | / | 0.440 |