sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3iej | 599 | Cathepsin S | 3.4.22.27 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3iej | 599 | Cathepsin S | 3.4.22.27 | 1.000 | |
| 3kwn | 23Z | Cathepsin S | 3.4.22.27 | 0.529 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.489 | |
| 3mpe | N2A | Cathepsin S | 3.4.22.27 | 0.469 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.458 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 4a6d | SAM | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.455 | |
| 3reo | SAH | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.454 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.450 | |
| 1q6s | 214 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.448 | |
| 3bhl | THG | Thymidylate synthase | / | 0.447 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.447 | |
| 1mxt | FAE | Cholesterol oxidase | 1.1.3.6 | 0.446 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.446 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.445 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.444 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.444 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.442 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.441 | |
| 1u9q | 186 | Cruzipain | 3.4.22.51 | 0.440 | |
| 3p9k | SAH | Caffeic acid O-methyltransferase | / | 0.440 |