scPDB - Distribution of Binding site Similarity values of 3ia4 entry / Site 4

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3ia4	MTX	Dihydrofolate reductase

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3ia4	MTX	Dihydrofolate reductase	/	1.000
2zza	FOL	Dihydrofolate reductase	/	0.615
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.589
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.575
3dau	MTX	Dihydrofolate reductase	1.5.1.3	0.563
3eel	53T	Uncharacterized protein	/	0.562
4ele	31I	Dihydrofolate reductase	/	0.561
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.556
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.552
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.552
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.551
2w3v	TOP	Dihydrofolate reductase	/	0.551
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.547
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.544
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.543
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.543
3cse	N22	Uncharacterized protein	/	0.541
3eek	53S	Uncharacterized protein	/	0.541
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.540
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.540
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.540
4h98	14Q	Uncharacterized protein	/	0.540
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.539
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.539
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.537
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.536
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.535
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.534
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.533
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.533
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.532
3qlz	QLZ	Uncharacterized protein	/	0.532
3qlx	QLR	Uncharacterized protein	/	0.531
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.530
3fl8	RAR	Dihydrofolate reductase	/	0.530
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.530
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.529
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.529
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.528
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.528
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.527
3sa2	7DR	Dihydrofolate reductase	/	0.527
3eem	53V	Uncharacterized protein	/	0.526
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.526
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.524
3eej	53R	Uncharacterized protein	/	0.524
3sa1	6DR	Dihydrofolate reductase	/	0.523
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.523
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.522
3qly	55V	Uncharacterized protein	/	0.522
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.522
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.521
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.520
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.520
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.518
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.517
4elg	52J	Dihydrofolate reductase	/	0.517
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.517
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.516
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.515
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.515
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.514
3tq9	MTX	Dihydrofolate reductase	/	0.512
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.509
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.507
3dat	MTX	Dihydrofolate reductase	/	0.505
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.505
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.504
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.503
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.501
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.501
4elf	35I	Dihydrofolate reductase	/	0.501
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.500
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.498
3fy9	XCF	Dihydrofolate reductase	1.5.1.3	0.498
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.498
3jw5	TOP	Dihydrofolate reductase	/	0.497
5hi6	MTX	Dihydrofolate reductase	/	0.497
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.496
4p66	MTX	Dihydrofolate reductase	/	0.496
3tqb	FOL	Dihydrofolate reductase	/	0.495
4elb	34S	Dihydrofolate reductase	/	0.493
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.492
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.491
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.491
3frf	XCF	Dihydrofolate reductase	1.5.1.3	0.490
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.488
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.488
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.487
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.486
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.486
3sai	9DR	Dihydrofolate reductase	/	0.484
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.483
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.483
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.482
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.482
2qk8	MTX	Dihydrofolate reductase	/	0.481
3jwm	5WB	Dihydrofolate reductase	/	0.478
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.478
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.474
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.474
4elb	34R	Dihydrofolate reductase	/	0.474
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.473
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.471
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.471
3fy8	XCF	Dihydrofolate reductase	1.5.1.3	0.469
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.468
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.467
1rg7	MTX	Dihydrofolate reductase	1.5.1.3	0.467
3ql3	FOL	Dihydrofolate reductase	1.5.1.3	0.467
4j03	FVS	Bifunctional epoxide hydrolase 2	3.1.3.76	0.465
2w3w	VG9	Dihydrofolate reductase	/	0.464
3sru	Q26	Dihydrofolate reductase	1.5.1.3	0.463
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.462
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.460
1dis	BDM	Dihydrofolate reductase	1.5.1.3	0.459
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.459
3gc9	B45	Mitogen-activated protein kinase 11	2.7.11.24	0.459
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
3srw	Q27	Dihydrofolate reductase	1.5.1.3	0.458
3fyv	XCF	Dihydrofolate reductase	1.5.1.3	0.457
3m08	RAR	Dihydrofolate reductase	1.5.1.3	0.457
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.456
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.455
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.454
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.452
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.452
3zep	1NX	Tyrosine-protein kinase JAK3	2.7.10.2	0.451
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
4gb9	0WR	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.451
1qzf	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.447
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.447
2har	OCC	Vitamin D3 receptor	/	0.447
4fgh	0U6	Dihydrofolate reductase	1.5.1.3	0.447
1e0a	GNP	Cell division control protein 42 homolog	/	0.446
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.444
3srs	M23	Dihydrofolate reductase	1.5.1.3	0.444
3kpz	ZNE	Vitamin D3 receptor	/	0.443
3u8h	BHP	Phospholipase A2, membrane associated	/	0.443
1e90	MYC	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.442
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.442
4j6d	TES	Cytochrome P450 monooxygenase	/	0.442
1ykd	CMP	Adenylate cyclase	/	0.441
2hb7	O1C	Vitamin D3 receptor	/	0.441
4ej7	ATP	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.441
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.440
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440
2w9g	TOP	Dihydrofolate reductase	1.5.1.3	0.440
3a1l	2CC	Cytochrome P450	/	0.440
3i8a	N22	Dihydrofolate reductase	1.5.1.3	0.440
3jw3	TOP	Dihydrofolate reductase	/	0.440
4cuk	NAI	D-lactate dehydrogenase	/	0.440