sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3htj | ET | EbrA repressor |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3htj | ET | EbrA repressor | / | 1.000 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.485 | |
| 3hth | PRL | EbrA repressor | / | 0.483 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.480 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.472 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.466 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.461 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.460 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.460 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.456 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.455 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.453 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.453 | |
| 1fml | RTL | Retinol dehydratase | / | 0.452 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.450 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.450 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.448 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.447 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.445 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.444 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.444 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.443 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.443 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.440 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.440 |