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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hb8UMPThymidylate synthase2.1.1.45

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hb8UMPThymidylate synthase2.1.1.451.000
4eb4UMPThymidylate synthase2.1.1.450.535
4e5oUMPThymidylate synthase2.1.1.450.523
2g89UMPThymidylate synthase/0.519
2g8aUMPThymidylate synthase/0.503
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.501
5by6UMPThymidylate synthase/0.500
1jmiUMPThymidylate synthase/0.498
1njbUMPThymidylate synthase/0.493
1tsvUMPThymidylate synthase/0.493
4dq1UMPThymidylate synthase/0.493
2g86UMPThymidylate synthase/0.492
1aobDDUThymidylate synthase/0.487
4xsdUMPThymidylate synthase2.1.1.450.486
1tsyUMPThymidylate synthase/0.483
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.481
4einNOHThymidylate synthase2.1.1.450.480
4psgNOHThymidylate synthase/0.477
1njeDCMThymidylate synthase/0.476
1njdUMPThymidylate synthase/0.474
1bpjUMPThymidylate synthase/0.473
1bduDURThymidylate synthase/0.472
1bidUMPThymidylate synthase/0.472
1jmgUMPThymidylate synthase/0.468
4irrUMPThymidylate synthase/0.468
2g8dUMPThymidylate synthase/0.465
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.461
2tdmUMPThymidylate synthase/0.460
1tsxUMPThymidylate synthase/0.459
1bp6UMPThymidylate synthase/0.456
1lcbTMPThymidylate synthase/0.453
1bp0UMPThymidylate synthase/0.451
1njaDCMThymidylate synthase/0.451
2tsrUMPThymidylate synthase2.1.1.450.451
3qj7UMPThymidylate synthase ThyA/0.450
1jmfUMPThymidylate synthase/0.441