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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3fu5492Leukotriene A-4 hydrolase3.3.2.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3fu5492Leukotriene A-4 hydrolase3.3.2.61.000
4rsyB3NLeukotriene A-4 hydrolase3.3.2.60.621
3ful52DLeukotriene A-4 hydrolase3.3.2.60.611
3fuj00GLeukotriene A-4 hydrolase3.3.2.60.604
3fui812Leukotriene A-4 hydrolase3.3.2.60.600
3chs4BULeukotriene A-4 hydrolase3.3.2.60.588
3fun798Leukotriene A-4 hydrolase3.3.2.60.517
3ndjJHZMethyltransferase/0.473
4rvgTYDD-mycarose 3-C-methyltransferase/0.470
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.465
3chr4BSLeukotriene A-4 hydrolase3.3.2.60.463
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.459
3rsv3RSBeta-secretase 13.4.23.460.459
3qe2FMNNADPH--cytochrome P450 reductase/0.457
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.453
1tllFMNNitric oxide synthase, brain1.14.13.390.452
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.452
1qzyTDEMethionine aminopeptidase 2/0.451
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.451
3gncQQQGlutaryl-CoA dehydrogenase/0.450
3rl45GPMetallophosphoesterase MPPED23.10.450
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.449
3s5wFADL-ornithine N(5)-monooxygenase/0.445
1odnAPVIsopenicillin N synthase1.21.3.10.444
3v0p4GWHisto-blood group ABO system transferase/0.444
1h36R88Squalene--hopene cyclase4.2.1.1290.443
1odjGMPPurine nucleoside phosphorylase/0.443
2y6fM9FIsopenicillin N synthase1.21.3.10.443
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.442
1nw4IMHPurine nucleoside phosphorylase/0.441
1x1bSAHC-20 methyltransferase/0.441
12gs0HHGlutathione S-transferase P2.5.1.180.440
1rkwPNTHTH-type transcriptional regulator QacR/0.440
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
4bftZVTPantothenate kinase2.7.1.330.440