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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3fpdSAHHistone-lysine N-methyltransferase EHMT1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3fpdSAHHistone-lysine N-methyltransferase EHMT1/1.000
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.630
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.619
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.604
3hnaSAHHistone-lysine N-methyltransferase EHMT1/0.563
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.562
5czySAMEukaryotic huntingtin interacting protein B/0.515
2rfiSAHHistone-lysine N-methyltransferase EHMT1/0.505
3swcSAHHistone-lysine N-methyltransferase EHMT1/0.491
3kmtSAHHistone H3K27 methylase/0.463
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.457
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.453
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.448
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.446
4ypeSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.444
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2gv8NDPThiol-specific monooxygenase1.14.130.442
2qimZEAClass 10 plant pathogenesis-related protein/0.442
3ru0SFGHistone-lysine N-methyltransferase SMYD32.1.1.430.441