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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3fkoFKOMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3fkoFKOMitogen-activated protein kinase 14/1.000
3fl4FL4Mitogen-activated protein kinase 14/0.810
3fknFKNMitogen-activated protein kinase 14/0.735
3fmmXI2Mitogen-activated protein kinase 14/0.641
2gfsPQBMitogen-activated protein kinase 14/0.622
3zsh469Mitogen-activated protein kinase 14/0.591
3itzP66Mitogen-activated protein kinase 14/0.583
3hub469Mitogen-activated protein kinase 14/0.580
1zzlTZYMitogen-activated protein kinase 14/0.555
1ove358Mitogen-activated protein kinase 14/0.532
3ds6A17Mitogen-activated protein kinase 14/0.529
1w7h3IPMitogen-activated protein kinase 14/0.504
3fi4FI4Mitogen-activated protein kinase 14/0.497
3gc9B45Mitogen-activated protein kinase 112.7.11.240.495
3rinI2OMitogen-activated protein kinase 14/0.495
3flwFLWMitogen-activated protein kinase 14/0.494
3c5uP41Mitogen-activated protein kinase 14/0.488
3e92G6AMitogen-activated protein kinase 14/0.488
2yixYIXMitogen-activated protein kinase 14/0.487
3flyFLYMitogen-activated protein kinase 14/0.486
1yqj6NPMitogen-activated protein kinase 14/0.481
3bx5304Mitogen-activated protein kinase 14/0.480
3fln3FNMitogen-activated protein kinase 14/0.477
3fmn530Mitogen-activated protein kinase 14/0.477
1zyjBI5Mitogen-activated protein kinase 14/0.475
3fmkFMKMitogen-activated protein kinase 14/0.473
3s4qNK0Mitogen-activated protein kinase 14/0.473
3fmh533Mitogen-activated protein kinase 14/0.472
3gc8B45Mitogen-activated protein kinase 112.7.11.240.472
1ouy094Mitogen-activated protein kinase 14/0.471
2vf0F89Thymidylate synthase/0.471
2vcmM11Isopenicillin N synthase1.21.3.10.470
4iarERM5-hydroxytryptamine receptor 1B/0.470
1synF89Thymidylate synthase/0.469
1wbwLI4Mitogen-activated protein kinase 14/0.469
2zb1GK4Mitogen-activated protein kinase 14/0.469
3hp552PMitogen-activated protein kinase 14/0.469
4lopSB4Mitogen-activated protein kinase 14/0.469
3flzFLZMitogen-activated protein kinase 14/0.467
3d7zGK5Mitogen-activated protein kinase 14/0.464
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.462
2po7CHDFerrochelatase, mitochondrial4.99.1.10.460
1kk4ACOStreptogramin A acetyltransferase2.3.10.457
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.457
2z3uCRRCytochrome P450/0.456
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.454
3hl7I47Mitogen-activated protein kinase 14/0.454
3pg3DG7Mitogen-activated protein kinase 14/0.454
2uxoTACHTH-type transcriptional regulator TtgR/0.453
4twpAXITyrosine-protein kinase ABL12.7.10.20.453
1m7qDQOMitogen-activated protein kinase 14/0.452
3roc29AMitogen-activated protein kinase 14/0.452
3nww3NWMitogen-activated protein kinase 14/0.451
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.451
4iaq2GM5-hydroxytryptamine receptor 1B/0.450
4ruoBIVVitamin D3 receptor A/0.450
1ywrLI9Mitogen-activated protein kinase 14/0.449
3vtbTKAVitamin D3 receptor/0.449
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
5k2bZMAAdenosine receptor A2a/0.449
1kzjCB3Thymidylate synthase/0.448
1hb3SCVIsopenicillin N synthase1.21.3.10.447
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.447
1qiqACCIsopenicillin N synthase1.21.3.10.446
2vbpVB1Isopenicillin N synthase1.21.3.10.446
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
1zhzERGOxysterol-binding protein homolog 4/0.444
3gfeP37Mitogen-activated protein kinase 14/0.444
3mvl38PMitogen-activated protein kinase 14/0.444
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.444
1f28F89Thymidylate synthase2.1.1.450.443
2hm9TRRDihydrofolate reductase1.5.1.30.443
3fc152PMitogen-activated protein kinase 14/0.443
3fklFKLMitogen-activated protein kinase 14/0.443
3vt9YI4Vitamin D3 receptor/0.443
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.442
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.441
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.441
3ttjJBIMitogen-activated protein kinase 102.7.11.240.441
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
4jlj1NMDeoxycytidine kinase2.7.1.740.441
4looSB4Mitogen-activated protein kinase 14/0.441
1bk0ACVIsopenicillin N synthase1.21.3.10.440
3uvqFS8Mitogen-activated protein kinase 14/0.440
5dozNDPJamJ/0.440