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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ffkATPActin, alpha skeletal muscle

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ffkATPActin, alpha skeletal muscle/1.000
1rgiATPActin, alpha skeletal muscle/0.612
1t44ATPActin, alpha skeletal muscle/0.593
1c0fATPMajor actin/0.584
3m6gATPActin, alpha skeletal muscle/0.584
5ce3ATPActin/0.580
3u9dATPActin, alpha skeletal muscle/0.578
4pl8ATPActin, alpha skeletal muscle/0.571
4pkgATPActin, alpha skeletal muscle/0.565
1h1vATPActin, alpha skeletal muscle/0.564
4jhdANPActin-5C/0.564
1qz5ATPActin, alpha skeletal muscle/0.561
3tu5ATPActin, alpha skeletal muscle/0.561
1s22ATPActin, alpha skeletal muscle/0.559
3mn6ATPActin-5C/0.559
4k42ADPActin, alpha skeletal muscle/0.556
2q36ATPActin, alpha skeletal muscle/0.555
1eqyATPActin, alpha skeletal muscle/0.550
1ijjATPActin, alpha skeletal muscle/0.550
3el2ATPActin-5C/0.544
1lotATPActin, alpha skeletal muscle/0.541
4cbxATPActin-2/0.541
1nmdATPMajor actin/0.539
4k41ATPActin, alpha skeletal muscle/0.536
3a5mATPMajor actin/0.535
4ci6ATPActin/0.533
2q97ATPActin, alpha skeletal muscle/0.532
4k43ADPActin, alpha skeletal muscle/0.531
2v51ATPActin, alpha skeletal muscle/0.525
3m1fATPActin, alpha skeletal muscle/0.524
3w3dATPActin, gamma-enteric smooth muscle/0.520
1yxqATPActin, alpha skeletal muscle/0.519
3mn9ATPActin-5C/0.519
1nm1ATPMajor actin/0.517
1mduATPActin, alpha skeletal muscle/0.516
4m63ATPActin-5C/0.514
3mn7ATPActin-5C/0.509
4pkiATPActin, alpha skeletal muscle/0.508
4pkhADPActin, alpha skeletal muscle/0.505
1kxpATPActin, alpha skeletal muscle/0.499
3dawATPActin, alpha skeletal muscle/0.494
3u4lATPActin, cytoplasmic 1/0.491
4rwtANPActin-5C/0.490
1dejATPMajor actin/0.483
2oanATPActin, cytoplasmic 1/0.480
3eksATPActin-5C/0.480
2p9kATPActin-related protein 2/0.479
1nlvATPMajor actin/0.471
2a41ATPActin, alpha skeletal muscle/0.466
3chwATPMajor actin/0.462
1wuaATPActin, alpha skeletal muscle/0.460
3ekuATPActin-5C/0.450
3a5oATPMajor actin/0.449