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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.21.000
3f47I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.692
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.664
3h65I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.664
3dafFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.565
3wmxNADNAD dependent epimerase/dehydratase/0.488
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.471
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.449
3ajrNADNDP-sugar epimerase/0.447
4b7xNAPProbable oxidoreductase/0.446
2q5g1FAPeroxisome proliferator-activated receptor delta/0.445
2vojNADAlanine dehydrogenase1.4.1.10.444
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.443
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.442
2ylrFADPhenylacetone monooxygenase1.14.13.920.441
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.440
4l04NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440