sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 1.000 | |
| 2rbe | ZMG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.535 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.522 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.510 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.502 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.499 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.487 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.487 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.486 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.480 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.479 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.475 | |
| 3up0 | D7S | aceDAF-12 | / | 0.472 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.468 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.467 | |
| 1osv | CHC | Bile acid receptor | / | 0.465 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.465 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.464 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.461 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.461 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.459 | |
| 3bzu | A21 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.457 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.456 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.455 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.454 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.454 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.453 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.452 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.452 | |
| 3up3 | XCA | aceDAF-12 | / | 0.452 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.452 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.451 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.451 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.450 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.449 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.449 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.449 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.448 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.448 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.448 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.448 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 2eix | FAD | NADH-cytochrome b5 reductase | / | 0.447 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.447 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.447 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 3aba | FLI | Cytochrome P450 | / | 0.446 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.446 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4iah | 1DX | Alr2278 protein | / | 0.445 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.444 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.442 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.441 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.441 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.441 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.440 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 1q6s | 214 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.440 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.440 | |
| 4l8u | 9AZ | Serum albumin | / | 0.440 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.440 |