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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3eq9X97Prolyl endopeptidase3.4.21.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3eq9X97Prolyl endopeptidase3.4.21.261.000
1uopGLY_PHE_GLU_PROProlyl endopeptidase3.4.21.260.699
4bcdTDVProlyl endopeptidase3.4.21.260.642
1uoqGLU_PHE_SER_PROProlyl endopeptidase3.4.21.260.630
1uooGLY_PHE_ARG_PROProlyl endopeptidase3.4.21.260.618
1e8mP0HProlyl endopeptidase3.4.21.260.591
3jzdNADMaleylacetate reductase/0.466
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.465
5burATP2-succinylbenzoate--CoA ligase/0.465
1yidATPTryptophan--tRNA ligase 26.1.1.20.456
4jb1NAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.456
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.451
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.451
3fccATPD-alanine--poly(phosphoribitol) ligase subunit 1/0.451
3hdyFDAUDP-galactopyranose mutase/0.451
4jayNAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.451
1iqrFADDeoxyribodipyrimidine photo-lyase4.1.99.30.450
2geuCOKPantothenate kinase2.7.1.330.446
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.445
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.445
3wqmB29Diterpene synthase3.1.7.80.445
4q0kGA3Phytohormone-binding protein/0.445
3ge6FMNNitroreductase/0.444
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3hyoADPPyridoxal kinase/0.443
3ivmZPRProlyl endopeptidase/0.443
4bmvNAPShort-chain dehydrogenase/0.443
1jmgUMPThymidylate synthase/0.442
4bfxZVXPantothenate kinase2.7.1.330.442
2yxuATPPyridoxal kinase2.7.1.350.441
1pqc444Oxysterols receptor LXR-beta/0.440
4gxs0YSGlutamate receptor 2/0.440