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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/1.000
3e34ED1Protein farnesyltransferase subunit beta2.5.1.581.000
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.594
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.547
1s63778Protein farnesyltransferase subunit beta2.5.1.580.536
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.527
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.520
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.519
3sfy3FYUncharacterized protein/0.517
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.512
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.512
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.512
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.511
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.511
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.504
3q7fED2Uncharacterized protein/0.501
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.500
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.495
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.484
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.479
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.444