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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.689
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.681
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.664
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.658
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.657
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.639
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.633
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.629
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.622
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.615
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.612
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.607
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.595
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.595
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.593
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.586
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.565
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.564
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.556
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.506
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
3v94WYQPhosphodiesterase/0.472
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.465
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.460
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440