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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3chwATPMajor actin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3chwATPMajor actin/1.000
1nlvATPMajor actin/0.605
3ekuATPActin-5C/0.595
4jhdANPActin-5C/0.592
4pl8ATPActin, alpha skeletal muscle/0.589
3mn6ATPActin-5C/0.587
3m6gATPActin, alpha skeletal muscle/0.582
1c0fATPMajor actin/0.578
3a5mATPMajor actin/0.576
4pkgATPActin, alpha skeletal muscle/0.567
1lotATPActin, alpha skeletal muscle/0.563
5ce3ATPActin/0.563
1t44ATPActin, alpha skeletal muscle/0.562
2q36ATPActin, alpha skeletal muscle/0.561
1nm1ATPMajor actin/0.560
1s22ATPActin, alpha skeletal muscle/0.557
3mn9ATPActin-5C/0.556
1qz5ATPActin, alpha skeletal muscle/0.555
1rgiATPActin, alpha skeletal muscle/0.552
2q97ATPActin, alpha skeletal muscle/0.550
4pkhADPActin, alpha skeletal muscle/0.543
4k41ATPActin, alpha skeletal muscle/0.541
4k42ADPActin, alpha skeletal muscle/0.541
1wuaATPActin, alpha skeletal muscle/0.538
3ffkATPActin, alpha skeletal muscle/0.532
4cbxATPActin-2/0.532
3tu5ATPActin, alpha skeletal muscle/0.523
4m63ATPActin-5C/0.523
2v51ATPActin, alpha skeletal muscle/0.521
3mn7ATPActin-5C/0.515
4ci6ATPActin/0.514
1nmdATPMajor actin/0.512
3u9dATPActin, alpha skeletal muscle/0.512
1h1vATPActin, alpha skeletal muscle/0.511
1yxqATPActin, alpha skeletal muscle/0.509
3u4lATPActin, cytoplasmic 1/0.505
3eksATPActin-5C/0.497
2p9kATPActin-related protein 2/0.490
4k43ADPActin, alpha skeletal muscle/0.489
4rwtANPActin-5C/0.489
1ijjATPActin, alpha skeletal muscle/0.486
3dawATPActin, alpha skeletal muscle/0.483
2oanATPActin, cytoplasmic 1/0.477
1eqyATPActin, alpha skeletal muscle/0.467