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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.146

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1461.000
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.606
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.599
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.569
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.566
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.565
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.550
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.547
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.545
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.541
3tfq07MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.530
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.530
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.527
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.521
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.519
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.519
2rbeZMGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.516
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.513
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.512
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.502
3bzuA21Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.499
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.499
1fmlRTLRetinol dehydratase/0.467
1x8lOXRRetinol dehydratase/0.466
2bu9HFVIsopenicillin N synthase1.21.3.10.466
1osvCHCBile acid receptor/0.464
2jn3JN3Fatty acid-binding protein, liver/0.456
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.454
1fmjRTLRetinol dehydratase/0.453
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.451
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.451
3d7kD7KBenzaldehyde lyase/0.449
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.449
1q23FUAChloramphenicol acetyltransferase2.3.1.280.448
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.448
4jlj1NMDeoxycytidine kinase2.7.1.740.447
3gw9VNILanosterol 14-alpha-demethylase/0.445
2xveFADPutative flavin-containing monooxygenase/0.444
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
2po7CHDFerrochelatase, mitochondrial4.99.1.10.443
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3vtcTK3Vitamin D3 receptor/0.443
4g3jVNTLanosterol 14-alpha-demethylase/0.443
2ok7FADFerredoxin--NADP reductase, apicoplast/0.442
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.442
4pd6URINucleoside permease/0.442
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
3sn6P0GBeta-2 adrenergic receptor/0.441
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.440
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2q9fC3SCholesterol 24-hydroxylase/0.440
2y60M8FIsopenicillin N synthase1.21.3.10.440