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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3acy702Dehydrosqualene synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3acy702Dehydrosqualene synthase/1.000
3tfn2CJDehydrosqualene synthase/0.621
4ea13RXDehydrosqualene synthase/0.599
4ea0651Dehydrosqualene synthase/0.570
3acw651Dehydrosqualene synthase/0.545
3tfp03LDehydrosqualene synthase/0.542
2zcqB65Dehydrosqualene synthase/0.535
4f6xZYLDehydrosqualene synthase/0.485
4ea2RWZDehydrosqualene synthase/0.474
4f6vZYMDehydrosqualene synthase/0.461
3ebf332Nitric oxide synthase, inducible1.14.13.390.457
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
5irnADPNucleotide binding oligomerization domain containing 2/0.447
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
4nieNBHNuclear receptor ROR-gamma/0.444
1oc1ASVIsopenicillin N synthase1.21.3.10.443
1ezfIN0Squalene synthase2.5.1.210.442
1dv2ATPBiotin carboxylase6.3.4.140.441