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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a0tADPSensor histidine kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a0tADPSensor histidine kinase/1.000
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.504
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.493
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.485
1nhhANPDNA mismatch repair protein MutL/0.479
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.475
1w6hTITPlasmepsin-23.4.23.390.467
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.464
2y0mACOHistone acetyltransferase KAT8/0.462
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.462
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.459
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.458
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
1g1aNADdTDP-glucose 4,6-dehydratase/0.455
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.455
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.454
3lqfNADGalactitol dehydrogenase/0.453
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.452
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3mk6ACOPantothenate kinase 32.7.1.330.449
1bwsNDPGDP-L-fucose synthase/0.448
5a3bAPRSIR2 family protein/0.446
1xe55FEPlasmepsin-23.4.23.390.445
2iviACWIsopenicillin N synthase1.21.3.10.445
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
2bu9HFVIsopenicillin N synthase1.21.3.10.444
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.444
4prvADPDNA gyrase subunit B/0.444
2fj1CTCTetracycline repressor protein class D/0.442
2he5NDPAldo-keto reductase family 1 member C211.1.10.442
2xpuTDCTetracycline repressor protein class D/0.442
4pzrCOAHistone acetyltransferase p300/0.441
1thnADPAnti-sigma F factor/0.440