scPDB - Distribution of Binding site Similarity values of 2zza entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2zza	FOL	Dihydrofolate reductase

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2zza	FOL	Dihydrofolate reductase	/	1.000
3ia4	MTX	Dihydrofolate reductase	/	0.599
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.558
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.549
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.548
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.540
4ele	31I	Dihydrofolate reductase	/	0.536
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.530
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.529
3dat	MTX	Dihydrofolate reductase	/	0.527
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.521
3fl8	RAR	Dihydrofolate reductase	/	0.518
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.517
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.516
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.516
3eek	53S	Uncharacterized protein	/	0.516
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.516
3dau	MTX	Dihydrofolate reductase	1.5.1.3	0.514
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.514
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.513
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.512
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.512
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.511
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.509
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.507
3cse	N22	Uncharacterized protein	/	0.507
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.507
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.506
3sa2	7DR	Dihydrofolate reductase	/	0.506
3eej	53R	Uncharacterized protein	/	0.505
3sa1	6DR	Dihydrofolate reductase	/	0.504
3qly	55V	Uncharacterized protein	/	0.503
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.501
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.501
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.499
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.499
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.498
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.498
4elb	34S	Dihydrofolate reductase	/	0.498
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.497
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.496
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.496
2w3v	TOP	Dihydrofolate reductase	/	0.494
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.491
3eel	53T	Uncharacterized protein	/	0.491
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.491
3qlx	QLR	Uncharacterized protein	/	0.491
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.490
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.490
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.490
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.490
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.487
4p66	MTX	Dihydrofolate reductase	/	0.487
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.486
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.485
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.485
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.484
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.484
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.482
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.482
4h98	14Q	Uncharacterized protein	/	0.481
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.480
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.480
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.480
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.480
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.480
1rg7	MTX	Dihydrofolate reductase	1.5.1.3	0.479
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.479
3tq9	MTX	Dihydrofolate reductase	/	0.479
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.478
4elg	52J	Dihydrofolate reductase	/	0.476
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.476
5hi6	MTX	Dihydrofolate reductase	/	0.476
7dfr	FOL	Dihydrofolate reductase	1.5.1.3	0.476
3fy9	XCF	Dihydrofolate reductase	1.5.1.3	0.475
4elf	35I	Dihydrofolate reductase	/	0.475
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.475
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.473
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.472
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.472
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.470
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.470
3qlz	QLZ	Uncharacterized protein	/	0.470
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.469
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.469
1dis	BDM	Dihydrofolate reductase	1.5.1.3	0.468
1qzf	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.468
3jw5	TOP	Dihydrofolate reductase	/	0.468
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.466
3eem	53V	Uncharacterized protein	/	0.465
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.465
3frf	XCF	Dihydrofolate reductase	1.5.1.3	0.464
3fyv	XCF	Dihydrofolate reductase	1.5.1.3	0.463
3tqb	FOL	Dihydrofolate reductase	/	0.463
2qk8	MTX	Dihydrofolate reductase	/	0.462
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.462
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.461
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.461
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.460
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.460
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.458
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.458
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.458
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.457
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.455
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.454
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.454
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.454
3srs	M23	Dihydrofolate reductase	1.5.1.3	0.454
4elb	34R	Dihydrofolate reductase	/	0.454
4elh	53I	Dihydrofolate reductase	/	0.453
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.453
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.451
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.451
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.449
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.447
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.447
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.446
3jwc	EKB	Dihydrofolate reductase	/	0.446
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.443
3sai	9DR	Dihydrofolate reductase	/	0.443
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.442
3fy8	XCF	Dihydrofolate reductase	1.5.1.3	0.440
3qaq	QAQ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.440