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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zjwREFCasein kinase II subunit alpha2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zjwREFCasein kinase II subunit alpha2.7.11.11.000
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.489
3juhANPCasein kinase II subunit alpha2.7.11.10.475
3lltANPProtein serine/threonine kinase-1/0.473
3u4uLNHCasein kinase II subunit alpha2.7.11.10.473
4anmWULCasein kinase II subunit alpha2.7.11.10.469
3pe2E1BCasein kinase II subunit alpha2.7.11.10.465
4grb0XGCasein kinase II subunit alpha2.7.11.10.465
3i60E86Mitogen-activated protein kinase 12.7.11.240.464
2vu3LZECyclin-dependent kinase 22.7.11.220.463
3be9P04Casein kinase II subunit alpha2.7.11.10.461
3begANPSRSF protein kinase 12.7.11.10.457
2pvnP63Casein kinase II subunit alpha2.7.11.10.456
3q9xEMOCasein kinase II subunit alpha2.7.11.10.454
3at4CCKCasein kinase II subunit alpha2.7.11.10.452
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2fvdLIACyclin-dependent kinase 22.7.11.220.446
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.445
3bqr4RBDeath-associated protein kinase 3/0.445
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.445
3mb714ICasein kinase II subunit alpha2.7.11.10.443
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.443
1aq1STUCyclin-dependent kinase 22.7.11.220.442
2vttLZDCyclin-dependent kinase 22.7.11.220.442
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.442
4aguD15Cyclin-dependent kinase-like 1/0.442
5cvfATPCasein kinase II subunit alpha2.7.11.10.442
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.441
2r3p3SCCyclin-dependent kinase 22.7.11.220.441
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440
5av2KMPDeath-associated protein kinase 12.7.11.10.440