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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xpwOTCTetracycline repressor protein class D

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xpwOTCTetracycline repressor protein class D/1.000
2trtTACTetracycline repressor protein class D/0.679
5fklTDCTetracycline repressor protein class D/0.663
4auxXTCTetracycline repressor protein class D/0.660
5fkmTDCTetracycline repressor protein class D/0.628
4d7mTDCTetracycline repressor protein class D/0.627
2xpuTDCTetracycline repressor protein class D/0.617
2vkeTACTetracycline repressor protein class D/0.609
4b3aTACTetracycline repressor protein class D/0.606
2xpvMIYTetracycline repressor protein class D/0.597
1orkATCTetracycline repressor protein class D/0.588
4abzT1CTetracycline repressor protein class D/0.588
2o7oDXTTetracycline repressor protein class D/0.569
2tctCTCTetracycline repressor protein class D/0.567
2xb5I7TTetracycline repressor protein class D/0.564
2vkvTDCTetracycline repressor protein class D/0.550
2xrlDXTTetracycline repressor protein class D/0.544
5fkoTDCTetracycline repressor protein class D/0.533
2fj1CTCTetracycline repressor protein class D/0.528
2vprTDCTetracycline repressor protein class H/0.520
4b1rITCTetracycline repressor protein class D/0.518
4v2gITCTetracycline repressor protein class D/0.499
5fknTDCTetracycline repressor protein class D/0.488
2x9dITCTetracycline repressor protein class D/0.478
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.460
1w6hTITPlasmepsin-23.4.23.390.447