Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xk730ESerine/threonine-protein kinase Nek22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xk730ESerine/threonine-protein kinase Nek22.7.11.11.000
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.609
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.594
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.590
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.552
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.522
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.520
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.507
2owb626Serine/threonine-protein kinase PLK12.7.11.210.503
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.502
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.493
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.474
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.472
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.470
2z2w770Wee1-like protein kinase2.7.10.20.470
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.469
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.468
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.467
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.467
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.464
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.463
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.457
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.456
3ctj320Hepatocyte growth factor receptor2.7.10.10.456
5k2dZMAAdenosine receptor A2a/0.456
2xnoED8Serine/threonine-protein kinase Nek22.7.11.10.452
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.449
3deiRXBCaspase-33.4.22.560.449
5dozNDPJamJ/0.447
1xddAAYIntegrin alpha-L/0.446
1pkfEPDEpothilone C/D epoxidase1.140.444
5uviZMAAdenosine receptor A2a/0.442
5ab7MLCNonspecific lipid-transfer protein, putative/0.441
5iua6DXAdenosine receptor A2a/0.441
3dejRXCCaspase-33.4.22.560.440
4b4vL34Bifunctional protein FolD/0.440
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.440
4fnyI3KALK tyrosine kinase receptor2.7.10.10.440
4jqh1MFAlr2278 protein/0.440