scPDB - Distribution of Binding site Similarity values of 2w3a entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2w3a	TOP	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	1.000
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.632
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.621
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.603
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.600
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.592
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.592
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.591
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.587
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.583
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.582
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.576
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.555
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.553
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.549
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.542
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.533
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.532
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.531
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.530
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.523
3cse	N22	Uncharacterized protein	/	0.521
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.518
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.518
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.512
1dlr	MXA	Dihydrofolate reductase	1.5.1.3	0.511
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.511
4h98	14Q	Uncharacterized protein	/	0.509
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.509
3eek	53S	Uncharacterized protein	/	0.507
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.506
3qly	55V	Uncharacterized protein	/	0.498
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.494
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.490
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.490
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.489
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.488
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.484
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.484
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.479
3eej	53R	Uncharacterized protein	/	0.479
3eem	53V	Uncharacterized protein	/	0.479
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.479
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.479
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.475
3qlz	QLZ	Uncharacterized protein	/	0.475
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.475
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.475
3eel	53T	Uncharacterized protein	/	0.473
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.472
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.471
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.468
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.466
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.465
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.465
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.463
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.462
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.462
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.461
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.461
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.459
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.459
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.457
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.457
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.457
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.456
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.456
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.455
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.454
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.454
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.453
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.451
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.450
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.449
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.447
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.447
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.446
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.446
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.445
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.443
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.442
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.442
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.442
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.442
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.441
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.440
4anu	EM7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.440
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.440