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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2w0jZATSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2w0jZATSerine/threonine-protein kinase Chk22.7.11.11.000
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.647
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.641
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.638
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.633
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.629
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.626
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.625
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.617
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.586
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.523
4jbpYPHAurora kinase A2.7.11.10.508
4jboWPHAurora kinase A2.7.11.10.501
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.483
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.479
3gu7ADPDeath-associated protein kinase 12.7.11.10.470
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
1jklANPDeath-associated protein kinase 12.7.11.10.467
2vrx447Aurora kinase B-A2.7.11.10.465
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.465
2c6eHPMAurora kinase A2.7.11.10.459
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.457
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.456
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.456
3w2sW2REpidermal growth factor receptor2.7.10.10.456
4fv9E71Mitogen-activated protein kinase 12.7.11.240.455
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.450
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.448
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.446
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.445
3bu5ATPInsulin receptor2.7.10.10.444
3hx4ANPCalmodulin-domain protein kinase 1/0.444
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.443
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.442
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.442
1bygSTUTyrosine-protein kinase CSK/0.440
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.440
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.440
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.440
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440