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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2v6oFADThioredoxin glutathione reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2v6oFADThioredoxin glutathione reductase/1.000
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.585
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.566
1grhFADGlutathione reductase, mitochondrial1.8.1.70.563
1grgFADGlutathione reductase, mitochondrial1.8.1.70.561
1greFADGlutathione reductase, mitochondrial1.8.1.70.558
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.558
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.558
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.552
1graFADGlutathione reductase, mitochondrial1.8.1.70.551
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.550
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.542
3grsFADGlutathione reductase, mitochondrial1.8.1.70.540
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.532
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.530
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.529
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.508
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.506
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.497
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.497
1gerFADGlutathione reductase1.8.1.70.484
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.480
1febFADTrypanothione reductase1.8.1.120.477
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.475
1grbFADGlutathione reductase, mitochondrial1.8.1.70.474
2r9zFADGlutathione amide reductase/0.451
4j56FADThioredoxin reductase 21.8.1.90.443
1bzlFADTrypanothione reductase1.8.1.120.440