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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2tprFADTrypanothione reductase1.8.1.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2tprFADTrypanothione reductase1.8.1.121.000
1tytFADTrypanothione reductase1.8.1.120.616
4la1FADThioredoxin glutathione reductase/0.613
2x8hFADThioredoxin glutathione reductase/0.599
1fecFADTrypanothione reductase1.8.1.120.577
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.577
2x8gFADThioredoxin glutathione reductase/0.574
1dncFADGlutathione reductase, mitochondrial1.8.1.70.551
4j57FADThioredoxin reductase 21.8.1.90.534
4b1bFADThioredoxin reductase1.8.1.90.533
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.528
2wbaFADTrypanothione reductase1.8.1.120.522
4em3FADCoenzyme A disulfide reductase/0.500
4eqxFADCoenzyme A disulfide reductase/0.479
1vf3GDNGlutathione S-transferase 32.5.1.180.475
2c29NAPDihydroflavonol 4-reductase/0.465
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.465
2zjmF1MBeta-secretase 13.4.23.460.461
4dbzNDPPutative ketoacyl reductase1.3.10.459
1xvaSAMGlycine N-methyltransferase2.1.1.200.458
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.455
2g1n1IGRenin3.4.23.150.454
2a94AP0L-lactate dehydrogenase1.1.1.270.451
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.450
2ou2ACOHistone acetyltransferase KAT5/0.450
1gcoNADGlucose 1-dehydrogenase1.1.1.470.449
1me6IVSPlasmepsin-23.4.23.390.449
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.447
3gncQQQGlutaryl-CoA dehydrogenase/0.447
3gqvNAPEnoyl reductase LovC10.447
1obnASVIsopenicillin N synthase1.21.3.10.445
2vbdV10Isopenicillin N synthase1.21.3.10.445
1xe55FEPlasmepsin-23.4.23.390.444
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.444
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3zoiM2WIsopenicillin N synthase1.21.3.10.444
1g6kNADGlucose 1-dehydrogenase1.1.1.470.443
2givACOHistone acetyltransferase KAT8/0.443
2y4gTIRTamL/0.443
1geeNADGlucose 1-dehydrogenase1.1.1.470.442
1uhhCZPAequorin-2/0.442
2ejzSAHDiphthine synthase/0.442
2wp5FADTrypanothione reductase/0.442