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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2tctCTCTetracycline repressor protein class D

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2tctCTCTetracycline repressor protein class D/1.000
2trtTACTetracycline repressor protein class D/0.662
2o7oDXTTetracycline repressor protein class D/0.661
1orkATCTetracycline repressor protein class D/0.650
2xpvMIYTetracycline repressor protein class D/0.647
2fj1CTCTetracycline repressor protein class D/0.643
2xrlDXTTetracycline repressor protein class D/0.642
4d7mTDCTetracycline repressor protein class D/0.641
4b3aTACTetracycline repressor protein class D/0.640
5fkmTDCTetracycline repressor protein class D/0.636
4abzT1CTetracycline repressor protein class D/0.635
4auxXTCTetracycline repressor protein class D/0.604
2xpwOTCTetracycline repressor protein class D/0.602
5fklTDCTetracycline repressor protein class D/0.599
2xpuTDCTetracycline repressor protein class D/0.581
5fkoTDCTetracycline repressor protein class D/0.577
2vkeTACTetracycline repressor protein class D/0.575
4v2gITCTetracycline repressor protein class D/0.568
4b1rITCTetracycline repressor protein class D/0.548
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.546
2vprTDCTetracycline repressor protein class H/0.542
2x6o2TCTetracycline repressor protein class D/0.531
2xb5I7TTetracycline repressor protein class D/0.531
2x9dITCTetracycline repressor protein class D/0.520
5fknTDCTetracycline repressor protein class D/0.518
2vkvTDCTetracycline repressor protein class D/0.515
3uceNDPDehydrogenase/0.453
1w6hTITPlasmepsin-23.4.23.390.451
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.450
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.449
4q71FADBifunctional protein PutA/0.448
2ok7FADFerredoxin--NADP reductase, apicoplast/0.445
2ebaFADPutative glutaryl-CoA dehydrogenase/0.443
3c212BADNA integrity scanning protein DisA/0.442
3tjzGNPADP-ribosylation factor 1/0.442
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.442
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.441
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.440
2dvlFADAcyl-CoA dehydrogenase/0.440