sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2qei | CXX | Na(+):neurotransmitter symporter (Snf family) |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2qei | CXX | Na(+):neurotransmitter symporter (Snf family) | / | 1.000 | |
| 2q6h | CXX | Na(+):neurotransmitter symporter (Snf family) | / | 0.844 | |
| 2qju | DSM | Na(+):neurotransmitter symporter (Snf family) | / | 0.518 | |
| 2q72 | IXX | Na(+):neurotransmitter symporter (Snf family) | / | 0.517 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.462 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.454 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.454 | |
| 4l9q | 9TP | Serum albumin | / | 0.454 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.453 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.451 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3gwu | SRE | Na(+):neurotransmitter symporter (Snf family) | / | 0.451 | |
| 3lpf | Z77 | Beta-glucuronidase | 3.2.1.31 | 0.451 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.451 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.450 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.448 | |
| 3i58 | 7NA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.446 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.445 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.444 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.442 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.441 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.441 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4iji | 99T | Glutathione S-transferase-like protein YibF | / | 0.441 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.440 |