sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 1.000 | |
| 2oiq | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.609 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.579 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.540 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.536 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.531 | |
| 4agw | NG7 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.496 | |
| 4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.493 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.487 | |
| 3hv5 | R24 | Mitogen-activated protein kinase 14 | / | 0.485 | |
| 5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.485 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.483 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.479 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.476 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.475 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.459 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.456 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.452 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 3dge | ADP | Sensor histidine kinase | / | 0.449 | |
| 4iah | 1DX | Alr2278 protein | / | 0.448 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1w29 | TS0 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2ejz | SAH | Diphthine synthase | / | 0.446 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.446 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.446 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.446 | |
| 4ksp | 1SU | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.440 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.440 |