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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2jleI15Reverse transcriptase/RNaseH

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2jleI15Reverse transcriptase/RNaseH/1.000
3c6tM14Gag-Pol polyprotein2.7.7.490.635
3lakKR1Gag-Pol polyprotein2.7.7.490.614
2wonZZEGag-Pol polyprotein2.7.7.490.605
4mfb29TGag-Pol polyprotein2.7.7.490.604
3lalKRVGag-Pol polyprotein2.7.7.490.602
4h4m494Gag-Pol polyprotein2.7.7.490.593
3c6uM22Gag-Pol polyprotein2.7.7.490.591
4h4o506Gag-Pol polyprotein2.7.7.490.586
3t1a5MAGag-Pol polyprotein2.7.7.490.581
4rw6494Gag-Pol polyprotein2.7.7.490.571
3tamM06Gag-Pol polyprotein2.7.7.490.561
3t195MAGag-Pol polyprotein2.7.7.490.559
3drpR8EGag-Pol polyprotein2.7.7.490.558
3dokGWJPol protein/0.555
2b5j3ACGag-Pol polyprotein2.7.7.490.551
3drrR8EGag-Pol polyprotein2.7.7.490.545
3is9AC7Gag-Pol polyprotein2.7.7.490.542
4rw4494Gag-Pol polyprotein2.7.7.490.529
3dmjGWEPol protein/0.521
2be2R22Gag-Pol polyprotein2.7.7.490.520
2ynfWHUGag-Pol polyprotein2.7.7.490.520
3dyaPZLGag-Pol polyprotein2.7.7.490.516
3dlgGWEGag-Pol polyprotein2.7.7.490.504
4lsl1YQGag-Pol polyprotein2.7.7.490.502
2ynhEURGag-Pol polyprotein2.7.7.490.495
3irxUDRGag-Pol polyprotein2.7.7.490.494
3qlhT27Gag-Pol polyprotein2.7.7.490.483
1c1bGCAGag-Pol polyprotein2.7.7.490.476
1rt1MKCGag-Pol polyprotein2.7.7.490.471
1tl3H20Gag-Pol polyprotein2.7.7.490.470
4g1qT27Gag-Pol polyprotein2.7.7.490.470
3bgrT27Gag-Pol polyprotein2.7.7.490.467
4i2pG73Gag-Pol polyprotein2.7.7.490.466
1jlcFTCGag-Pol polyprotein2.7.7.490.463
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.463
4ifvT27Gag-Pol polyprotein2.7.7.490.458
4iaq2GM5-hydroxytryptamine receptor 1B/0.457
2opsHBQGag-Pol polyprotein2.7.7.490.450
3e5aVX6Aurora kinase A2.7.11.10.449
4id5T27Gag-Pol polyprotein2.7.7.490.449
2zd1T27Gag-Pol polyprotein2.7.7.490.448
1tl1H18Gag-Pol polyprotein2.7.7.490.447
4b1fKRHGlutamate racemase/0.445
1fkoEFZGag-Pol polyprotein2.7.7.490.441
4g1y0VOVitamin D3 receptor A/0.441
1fmlRTLRetinol dehydratase/0.440
1o6rR19Squalene--hopene cyclase4.2.1.1290.440
5k2bZMAAdenosine receptor A2a/0.440