sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2jf9 | OHT | Estrogen receptor |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2jf9 | OHT | Estrogen receptor | / | 1.000 | |
| 1uom | PTI | Estrogen receptor | / | 0.577 | |
| 1yin | CM3 | Estrogen receptor | / | 0.574 | |
| 1sj0 | E4D | Estrogen receptor | / | 0.571 | |
| 1xp6 | AIU | Estrogen receptor | / | 0.565 | |
| 1err | RAL | Estrogen receptor | / | 0.556 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.555 | |
| 2bj4 | OHT | Estrogen receptor | / | 0.527 | |
| 2jfa | RAL | Estrogen receptor | / | 0.516 | |
| 1nde | MON | Estrogen receptor beta | / | 0.514 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.513 | |
| 2qe4 | JJ3 | Estrogen receptor | / | 0.509 | |
| 4ivw | 1GJ | Estrogen receptor | / | 0.490 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.485 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.483 | |
| 2pog | WST | Estrogen receptor | / | 0.478 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.465 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.463 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.460 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.460 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.458 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.457 | |
| 1osv | CHC | Bile acid receptor | / | 0.456 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.456 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.453 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.451 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.447 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.446 | |
| 4kio | G5K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.446 | |
| 1w87 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.445 | |
| 1yim | CM4 | Estrogen receptor | / | 0.445 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.445 | |
| 4apu | A2K | Progesterone receptor | / | 0.445 | |
| 4iw6 | 1GU | Estrogen receptor | / | 0.445 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.444 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.444 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.444 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.443 | |
| 3sqq | 99Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.443 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.442 | |
| 1rrm | APR | Lactaldehyde reductase | 1.1.1.77 | 0.441 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.440 |