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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2j8tNAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2j8tNAPAldose reductase1.1.1.211.000
1x96NAPAldose reductase1.1.1.210.774
1x98NAPAldose reductase1.1.1.210.723
2acqNAPAldose reductase1.1.1.210.656
1ah4NAPAldose reductase1.1.1.210.643
2acsNAPAldose reductase1.1.1.210.643
2iq0NAPAldose reductase1.1.1.210.643
1az2NAPAldose reductase1.1.1.210.623
1adsNAPAldose reductase1.1.1.210.618
3q65NAPAldose reductase1.1.1.210.616
2pf8NDPAldose reductase1.1.1.210.605
3q67NAPAldose reductase1.1.1.210.603
2pevNDPAldose reductase1.1.1.210.601
2pfhNDPAldose reductase1.1.1.210.601
3v36NAPAldose reductase1.1.1.210.593
1z8aNAPAldose reductase1.1.1.210.588
3h7rNAPAldo-keto reductase family 4 member C8/0.579
3o3rNAPAldose reductase-related protein 11.1.1.210.577
1c9wNAPAldose reductase-related protein 2/0.557
2acuNAPAldose reductase1.1.1.210.554
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.550
4g5dNDPProstaglandin F synthase1.1.1.1880.544
2hejNDPAldo-keto reductase family 1 member C211.1.10.543
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.536
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.535
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.531
3qkzNAPAldose reductase-related protein 11.1.1.210.531
4pmjNAPPutative oxidoreductase/0.530
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.524
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.524
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.522
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.518
4xzmNAPAldo-keto reductase family 1 member B101.1.10.512
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.507
3wczNAPAldo-keto reductase AKR2E4/0.505
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.502
1zgdNAPChalcone reductase/0.502
4jtqNAPAldo-keto reductase family 1 member C2/0.500
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.495
1s1rNAPAldo-keto reductase family 1 member C3/0.494
1ef3NAPAldose reductase1.1.1.210.490
2hdjNDPAldo-keto reductase family 1 member C2/0.485
2p5nNDPAldo-keto reductase family 1 member C211.1.10.481
4xo7NAPAldo-keto reductase family 1 member C2/0.480
4l1xNAPAldo-keto reductase family 1 member C2/0.477
2vdgNDPAldose reductase1.1.1.210.475
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.470
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.469
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.468
1vp5NAPOxidoreductase, aldo/keto reductase family/0.465
4xznNAPAldo-keto reductase family 1 member B101.1.10.464
1pz1NAPGeneral stress protein 69/0.462
4dz5NAPAldo-keto reductase family 1 member C3/0.461
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.459
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
5c7hNDPPutative oxidoreductase/0.457
1og6NAPOxidoreductase YdhF10.454
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.450
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.448
1lqaNDPProtein tas/0.441
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.441
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.440