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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2io9ADPBifunctional glutathionylspermidine synthetase/amidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2io9ADPBifunctional glutathionylspermidine synthetase/amidase/1.000
2io7ANPBifunctional glutathionylspermidine synthetase/amidase/0.574
4o4iACPTubulin tyrosine ligase/0.474
5iqiGNPBifunctional AAC/APH2.3.10.467
3rv4ADPBiotin carboxylase6.3.4.140.465
2vqdAP2Biotin carboxylase6.3.4.140.464
5bylGCPBifunctional AAC/APH2.3.10.461
2q14ADPPhosphohydrolase/0.455
1yb5NAPQuinone oxidoreductase1.6.5.50.452
4kcfAKMFAD-dependent oxidoreductase/0.450
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2io8ADPBifunctional glutathionylspermidine synthetase/amidase/0.448
3ethATPN5-carboxyaminoimidazole ribonucleotide synthase/0.446
3lmiATPMyosin heavy chain kinase A2.7.11.70.445
1st0GTGm7GpppX diphosphatase3.6.1.590.444
3q1kADPD-alanine--D-alanine ligase A6.3.2.40.444
3vpcADPGlutamate--LysW ligase ArgX6.3.20.444
4uz6SCRPalmitoleoyl-protein carboxylesterase NOTUM/0.444
1z2pACPInositol-tetrakisphosphate 1-kinase2.7.1.1340.442
5c1oANPD-alanine--D-alanine ligase/0.442